E-box

E-box

An E-box is a DNA sequence which usually lies upstream of a gene in a promoter region. The consensus sequence for the E-box element is CANNTG, with a palindromic canonical sequence of CACGTG.cite journal
quotes =
last = Chaudhary
first = Jaideep
authorlink =
coauthors = Michael K. Skinner
date =
year =
month =
title = Basic Helix-Loop-Helix Proteins Can Act at the E-Box within the Serum Response Element of the c-fos Promoter to Influence Hormone-Induced Promoter Activation in Sertoli Cells
journal = Molecular Endocrinology
volume = 12
issue = 5
pages = 774–786
issn =
pmid =
doi =
id =
url = http://mend.endojournals.org/cgi/content/full/13/5/774
language = English
format =
accessdate =
laysummary =
laysource =
laydate =
quote =
] Transcription factors containing the basic-helix-loop-helix protein structural motif typically bind to E-boxes or related variant sequences and enhance transcription of the downstream gene.

Proteins that interact with E-boxes

*BMAL-CLOCK

References


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