Receptor activity-modifying protein

protein
Name=Receptor activity-modifying protein 1
caption=


width=500px
HGNCid=9843
Symbol=RAMP1
AltSymbols=
EntrezGene= 10267
OMIM= 605153
RefSeq= NM_005855
UniProt= O60894
PDB=
ECnumber=
Chromosome=2
Arm=q
Band=36
LocusSupplementaryData=-37.1

protein
Name=Receptor activity-modifying protein 2
caption=


width=
HGNCid= 9844
Symbol=RAMP2
AltSymbols=
EntrezGene= 10266
OMIM= 605154
RefSeq= NM_005854
UniProt= O60895
PDB=
ECnumber=
Chromosome=17
Arm=q
Band=12
LocusSupplementaryData=-21.1

protein
Name=Receptor activity-modifying protein 3
caption=


width=
HGNCid= 9845
Symbol=RAMP3
AltSymbols=
EntrezGene= 10268
OMIM= 605155
RefSeq= NM_005856
UniProt= O60896
PDB=
ECnumber=
Chromosome=7
Arm=q
Band=13
LocusSupplementaryData=-p12

Receptor activity-modifying proteins (RAMPs) are a class of proteins which interact with and modulate the activities of several Class B G Protein-Coupled Receptors including the receptors for secretin, calcitonin (CT), glucagon, and vasoactive intestinal peptide (VIP).cite journal |author=Sexton PM, Morfis M, Tilakaratne N, Hay DL, Udawela M, Christopoulos G, Christopoulos A |title=Complexing receptor pharmacology: modulation of family B G protein-coupled receptor function by RAMPs|journal= Ann N Y Acad Sci |volume= 1070 |issue= |pages=90–104 |year= 2006 | pmid = 16888151 | doi=10.1196/annals.1317.076 ] There are three distinct types of RAMPs, designated RAMP1, RAMP2, and RAMP3, each encoded by a separate gene.cite journal |author=Young A |title=Amylin: Physiology and Pharmacology; Chapter 3: Receptor pharmacology|journal=Advances in Pharmacology |volume= 52 |issue= |pages=47–65 |year= 2005 | pmid = 16492540 | doi = 10.1016/S1054-3589(05)52003-9 ]

The association of CALCRL with different RAMP proteins produces different receptors:cite journal | author = McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM | title = RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor | journal = Nature | volume = 393 | issue = 6683 | pages = 333–9 | year = 1998 | month = May | pmid = 9620797 | doi = 10.1038/30666 | url = | issn = ] cite journal | author = Foord SM, Marshall FH | title = RAMPs: accessory proteins for seven transmembrane domain receptors | journal = Trends Pharmacol. Sci.| volume = 20 | issue = 5 | pages = 184–7 | year = 1999 | month = May | pmid = 10354609 | doi = 10.1016/S0165-6147(99)01347-4 | url =| issn = ]
* with RAMP1: produces a CGRP receptor
* with RAMP2: produces an adrenomedullin (AM) receptorcite journal | author = Kamitani S, Asakawa M, Shimekake Y, Kuwasako K, Nakahara K, Sakata T | title = The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells | journal = FEBS Lett. | volume = 448 | issue = 1 | pages = 111–4 | year = 1999 | month = April | pmid = 10217420 | doi = 10.1016/S0014-5793(99)00358-0 | url = | issn = ]
* with RAMP3: produces a dual CGRP/AM receptor

External links

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References