RAMP2

RAMP2

protein
name = receptor (G protein-coupled) activity modifying protein 2
caption =


width =
HGNCid = 9844
Symbol = RAMP2
AltSymbols =
EntrezGene = 10266
OMIM = 605154
RefSeq = NM_005854
UniProt = O60895
PDB =
ECnumber =
Chromosome = 17
Arm = q
Band = 12
LocusSupplementaryData = -q21.1

Receptor activity modifying protein 2, also known as RAMP2, is a human gene.cite web | title = Entrez Gene: RAMP2 | url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10266 | accessdate =] cite journal | author = McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM | title = RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor | journal = Nature | volume = 393 | issue = 6683 | pages = 333–9 | year = 1998 | month = May | pmid = 9620797 | doi = 10.1038/30666 | url = |issn = ]

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.

References


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