Caspase 13

Caspase 13

Caspase 13 is an enzyme known as a cysteine protease that was identified in cattle that is also called "Evolutionarily Related Interleukin-1β Converting Enzyme" (ERICE). It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. Although this enzyme was originally reported as a human caspase that could be activated by caspase 8, [cite journal |author=Humke EW, Ni J, Dixit VM |title=ERICE, a novel FLICE-activatable caspase |journal=J. Biol. Chem. |volume=273 |issue=25 |pages=15702–7 |year=1998 |pmid=9624166 |doi=10.1074/jbc.273.25.15702] later studies confirmed the gene identified for caspase 13 came from bovine origin, and is the likely orthologue of human caspase 4. [cite journal |author=Koenig U, Eckhart L, Tschachler E |title=Evidence that caspase-13 is not a human but a bovine gene |journal=Biochem. Biophys. Res. Commun. |volume=285 |issue=5 |pages=1150–4 |year=2001 |pmid=11478774 |doi=10.1006/bbrc.2001.5315] [ [http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=88319945 NCBI Sequence Viewer v2.0 ] ]

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