TLR 7

TLR 7

Toll-like receptor 7, also known as TLR7, is an immune gene possessed by humans and other mammals and additionally in avian species.

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summary_text = The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different pattern of expressionpatterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on human chromosome X. [cite web | title = Entrez Gene: TLR7 toll-like receptor 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51284| accessdate = ]
Imiquimod acts upon TLR 7.cite journal |author=Hemmi H, Kaisho T, Takeuchi O, "et al" |title=Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway |journal=Nat. Immunol. |volume=3 |issue=2 |pages=196–200 |year=2002 |pmid=11812998 |doi=10.1038/ni758]

TLR7 recognises single stranded RNA in endosomes, which is a common feature of viral genomes which are internalised by macrophages.

References

Further reading

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citations =
*cite journal | author=Lien E, Ingalls RR |title=Toll-like receptors. |journal=Crit. Care Med. |volume=30 |issue= 1 Suppl |pages= S1–11 |year= 2002 |pmid= 11782555 |doi=
*cite journal | author=Kaisho T, Akira S |title=Toll-like receptors as adjuvant receptors. |journal=Biochim. Biophys. Acta |volume=1589 |issue= 1 |pages= 1–13 |year= 2002 |pmid= 11909637 |doi=

External links

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