Mir-8/mir-141/mir-200 microRNA precursor family

The miR-8 microRNA precursor (homologous to miR-141, miR-200, miR-236), is a short non-coding RNAgene involved in gene regulation. miR-8 from Drosophila cite journal |author=Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T |title=Identification of novel genes coding for small expressed RNAs |journal=Science |volume=294 |issue=5543 |pages=853–8 |year=2001 |pmid=11679670 |doi=10.1126/science.1064921] ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000128 MI0000128] ), human and mouse miR-141 ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000166 MI0000166] , [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000457 MI0000457] ), miR-429 ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0001642 MI0001642] ), miR-200 ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000243 MI0000243] , [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000342 MI0000342] ) cite journal |author=Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T |title=New microRNAs from mouse and human |journal=RNA |volume=9 |issue=2 |pages=175–9 |year=2003 |pmid=12554859 |doi=] and miR-236 ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000311] )are expressed from the 3' arm of related precursor hairpins (represented here). Members of this precursor family have now been predicted or experimentally confirmed in a wide range of species ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000019 MIPF0000019] ). The bounds of the precursors are predicted based on conservation and base pairing and are not generally known.

Targets of miR-8

The atrophin gene has been shown to be a target of drosophila miR-8.cite journal | author = Karres JS, Hilgers V, Carrera I, Treisman J, Cohen SM | title = The Conserved microRNA MiR-8 Tunes Atrophin Levels to Prevent Neurodegeneration in Drosophila | journal = Cell | volume = 131 | issue = 1 | pages = 136–45 | year = 2007 | pmid = 17923093 | doi = 10.1016/j.cell.2007.09.020 | issn = ] It has also been suggested that this target is also conserved in mammalian miR-8.

The human miR-200c is likely to target the zinc finger transcription factor transcription factor 8 (TCF8) gene.cite journal | author = Hurteau GJ, Carlson JA, Spivack SD, Brock GJ | title = Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin | journal = Cancer Res. | volume = 67 | issue = 17 | pages = 7972–6 | year = 2007 | pmid = 17804704 | doi = 10.1158/0008-5472.CAN-07-1058 | issn = ]

References

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