Repression of heat shock gene expression (ROSE) element
- Repression of heat shock gene expression (ROSE) element
The repression of heat shock gene expression (ROSE) element is an RNA element found in the 5' UTR of some heat shock mRNAs. The ROSE element is a negative regulator of heat shock gene expression. The secondary structure is thought to be regulated by temperature. This regulation blocks access to the ribosome binding site under normal conditions. During heat shock however, the structure changes freeing the ribosome binding site and allowing expression to occur. [cite journal | last = Nocker | first = A | coauthors = Hausherr T, Balsiger S, Krstulovic NP, Hennecke H, Narberhaus F | year = 2001 | title = A mRNA-based thermosensor controls expression of rhizobial heat shock genes | journal = Nucleic Acids Res | volume = 29 | pages = 4800–4807 | pmid = 11726689 | doi = 10.1093/nar/29.23.4800] [cite journal | last = Balsiger | first = S | coauthors = Ragaz C, Baron C, Narberhaus F | year = 2004 | title = Replicon-specific regulation of small heat shock genes in Agrobacterium tumefaciens | journal = J Bacteriol | volume = 186 | pages = 6824–6829 | pmid = 15466035 | doi = 10.1128/JB.186.20.6824-6829.2004]
A partial structure of this RNA element was recently determined using NMR. [cite journal |author=Chowdhury S, Maris C, Allain FH, Narberhaus F |title=Molecular basis for temperature sensing by an RNA thermometer |journal=EMBO J. |volume=25 |issue=11 |pages=2487–97 |year=2006 |pmid=16710302 |doi=10.1038/sj.emboj.7601128] ]References
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