HIV gag stem loop 3 (GSL3)

HIV gag stem loop 3 (GSL3)

HIV gag stem loop 3 (GSL3) is an RNA element that is known to direct specific packaging of HIV-1 genomic RNA. Deletion of GSL3 leads to decreases in both viral RNA packaging and dimerisation. [cite journal | last = Damgaard | first = CK | coauthors = Andersen ES, Knudsen B, Gorodkin J, Kjems J | year = 2004 | title = RNA interactions in the 5' region of the HIV-1 genome | journal = J Mol Biol | volume = 336 | pages = 369–379 | pmid = 14757051 | doi = 10.1016/j.jmb.2003.12.010] [cite journal | last = Rong | first = L | coauthors = Russell RS, Hu J, Laughrea M, Wainberg MA, Liang C | year = 2003 | title = Deletion of stem-loop 3 is compensated by second-site mutations within the Gag protein of human immunodeficiency virus type 1 | journal = Virology | volume = 314 | pages = 221–228 | pmid = 14517075 | doi = 10.1016/S0042-6822(03)00405-7]

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