Primer binding site

Primer binding site

The primer binding site is a structured RNA element in the genomes of retroviruses to which tRNA(3)(Lys) binds to initiate reverse transcription [2] . It consists of 18 nucleotides and follows the U5 region of the 5'-long terminal repeat (LTR) of the retrovirus.

References

* [1] cite journal | last = Damgaard | first = CK | coauthors = Andersen ES, Knudsen B, Gorodkin J, Kjems J | year = 2004 | title = RNA interactions in the 5' region of the HIV-1 genome | journal = J Mol Biol | volume = 336 | pages = 369–379 | pmid = 14757051 | doi = 10.1016/j.jmb.2003.12.010
* [2] cite journal | last = Beerens | first = N | coauthors = Groot F, Berkhout B | year = 2001 | title = Initiation of HIV-1 reverse transcription is regulated by a primer activation signal | journal = J Biol Chem | volume = 276 | pages = 31247–31256 | pmid = 11384976 | doi = 10.1074/jbc.M102441200

External links

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