Trans-activation response element (TAR)
- Trans-activation response element (TAR)
The HIV trans-activation response (TAR) element is an RNA element which is known to be required for the trans-activation of the viral promoter and for virus replication. The TAR hairpin acts as a binding site for the Tat protein and this interaction stimulates the activity of the long terminal repeat promoter. [cite journal | last = Kulinski | first = T | coauthors = Olejniczak M, Huthoff H, Bielecki L, Pachulska-Wieczorek K, Das AT, Berkhout B, Adamiak RW | year = 2003 | title = The apical loop of the HIV-1 TAR RNA hairpin is stabilized by a cross-loop base pair | journal = J Biol Chem | volume = 278 | pages = 38892–38901 | pmid = 12882959 | doi = 10.1074/jbc.M301939200]
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