Vesicular monoamine transporter
- Vesicular monoamine transporter
The vesicular monoamine transporter is a transport protein located within the presynaptic cell. It acts upon synaptic vesicles.
Isoforms
It comprises the two isoforms:
* VMAT1
* VMAT2
ubstrates
Substrates for the transporter is mainly noradrenaline, adrenaline and isoprenaline. However, other substrates include dopamine, 5-HT, guanethidine and MPP+.[ cite book |author=Rang, H. P. |title=Pharmacology |publisher=Churchill Livingstone |location=Edinburgh |year=2003 |pages= |isbn=0-443-07145-4 |oclc= |doi= Page 167 ] ]Clinicial significance
It can be inhibited by reserpine and tetrabenazine.VMAT is the main target of methamphetamine. By acting as a competitive antagonist, methamphetamine blocks the presynaptic cell's ability to use VMAT to package the above mentioned neurotransmitters into vesicles. The result is increased neurotransimtter release that is not dependent on the phasic activity of the presynaptic cell.
References
Further reading
*cite journal |author=Kilbourn MR |title=In vivo radiotracers for vesicular neurotransmitter transporters |journal=Nucl. Med. Biol. |volume=24 |issue=7 |pages=615–9 |year=1997 |pmid=9352531 |doi=10.1016/S0969-8051(97)00101-7
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External links
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