TRAF6

TRAF6

TRAF6 is a TRAF human protein.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported. [cite web | title = Entrez Gene: TRAF6 TNF receptor-associated factor 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7189| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wajant H, Henkler F, Scheurich P |title=The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators. |journal=Cell. Signal. |volume=13 |issue= 6 |pages= 389–400 |year= 2001 |pmid= 11384837 |doi=
*cite journal | author=Bradley JR, Pober JS |title=Tumor necrosis factor receptor-associated factors (TRAFs). |journal=Oncogene |volume=20 |issue= 44 |pages= 6482–91 |year= 2001 |pmid= 11607847 |doi= 10.1038/sj.onc.1204788
*cite journal | author=Tanaka S, Nakamura K, Takahasi N, Suda T |title=Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system. |journal=Immunol. Rev. |volume=208 |issue= |pages= 30–49 |year= 2006 |pmid= 16313339 |doi= 10.1111/j.0105-2896.2005.00327.x

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • TRAF6 — TNF receptor associated factor 6 Обозначения …   Википедия

  • MAP3K7IP2 — Mitogen activated protein kinase kinase kinase 7 interacting protein 2, also known as MAP3K7IP2, is a human gene.cite journal | author = Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya Tsuji J, Matsumoto K | title = TAB2 …   Wikipedia

  • MAP3K7 — Митоген активируемая киназа киназы протеинкиназы 7 Обозначения …   Википедия

  • MAP3K7IP2 — Proteína de interacción 2 con la MAP quinasa quinasa quinasa 7 Estructura tridimensional de la proteína MAP3K7IP2. HUGO …   Wikipedia Español

  • IKBKG — Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase gamma Rendering based on PDB 2JVX …   Wikipedia

  • IRAK1 — Interleukin 1 receptor associated kinase 1, also known as IRAK1, is a human gene. PBB Summary section title = summary text = This gene encodes the interleukin 1 receptor associated kinase 1, one of two putative serine/threonine kinases that… …   Wikipedia

  • MAST2 — Microtubule associated serine/threonine kinase 2, also known as MAST2, is a human gene.cite web | title = Entrez Gene: MAST2 microtubule associated serine/threonine kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • ASK1 — Mitogen activated protein kinase kinase kinase 5 PDB rendering based on 2clq …   Wikipedia

  • MAP3K7IP1 — Proteína de interacción 1 con la MAP quinasa quinasa quinasa 7 Estructura tridimensional de la proteína MAP3K7IP1. HUGO …   Wikipedia Español

  • Ubiquitina C — Estructura tridimensional de la ubiquitina C. HUGO 12468 …   Wikipedia Español

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”