GAB2

GRB2-associated binding protein 2, also known as GAB2, is a human gene.cite web | title = Entrez Gene: GAB2 GRB2-associated binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9846| accessdate = ]

The protein encoded by this gene, GAB2 is an adaptor protein serving as principal activator of Phosphatidylinositol 3-kinase. 10 SNPs of GAB2 gene have been found in one study to associate with risk of Alzheimer's disease in the carriers of ApoE4 allele.cite journal |author=Reiman EM, Webster JA, Myers AJ, Hardy J, Dunckley T, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Liang WS, Herbert RH, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem M, Mastroeni D, Grover A, Heward CB, Ravid R, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Kukull W, Papassotiropoulos A, Stephan DA |title=GAB2 Alleles Modify Alzheimer's Risk in APOE varepsilon4 Carriers |journal= |volume=54 |issue=5 |pages=713–720 |year=2007 |pmid=17553421 |doi=10.1016/j.neuron.2007.05.022 [http://www.neuron.org/content/article/fulltext?uid=PIIS0896627307003790&highlight=GAB2 Free full text] [http://download.neuron.org/pdfs/0896-6273/PIIS0896627307003790.pdf Free PDF] [http://www.tgen.org/research/index.cfm?pageid=1065 Genetic data in the public domain] ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hibi M, Hirano T |title=Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors. |journal=Leuk. Lymphoma |volume=37 |issue= 3-4 |pages= 299–307 |year= 2000 |pmid= 10752981 |doi=
*cite journal | author=Gold MR, Ingham RJ, McLeod SJ, "et al." |title=Targets of B-cell antigen receptor signaling: the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway and the Rap1 GTPase. |journal=Immunol. Rev. |volume=176 |issue= |pages= 47–68 |year= 2001 |pmid= 11043767 |doi=
*cite journal | author=Nagase T, Ishikawa K, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=
*cite journal | author=Nishida K, Yoshida Y, Itoh M, "et al." |title=Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. |journal=Blood |volume=93 |issue= 6 |pages= 1809–16 |year= 1999 |pmid= 10068651 |doi=
*cite journal | author=Zhao C, Yu DH, Shen R, Feng GS |title=Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1. |journal=J. Biol. Chem. |volume=274 |issue= 28 |pages= 19649–54 |year= 1999 |pmid= 10391903 |doi=
*cite journal | author=Wickrema A, Uddin S, Sharma A, "et al." |title=Engagement of Gab1 and Gab2 in erythropoietin signaling. |journal=J. Biol. Chem. |volume=274 |issue= 35 |pages= 24469–74 |year= 1999 |pmid= 10455108 |doi=
*cite journal | author=Bone H, Welham MJ |title=Shc associates with the IL-3 receptor beta subunit, SHIP and Gab2 following IL-3 stimulation. Contribution of Shc PTB and SH2 domains. |journal=Cell. Signal. |volume=12 |issue= 3 |pages= 183–94 |year= 2000 |pmid= 10704825 |doi=
*cite journal | author=Liu Y, Jenkins B, Shin JL, Rohrschneider LR |title=Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase. |journal=Mol. Cell. Biol. |volume=21 |issue= 9 |pages= 3047–56 |year= 2001 |pmid= 11287610 |doi= 10.1128/MCB.21.9.3047-3056.2001
*cite journal | author=Crouin C, Arnaud M, Gesbert F, "et al." |title=A yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partners. |journal=FEBS Lett. |volume=495 |issue= 3 |pages= 148–53 |year= 2001 |pmid= 11334882 |doi=
*cite journal | author=Bouscary D, Lecoq-Lafon C, Chrétien S, "et al." |title=Role of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo). |journal=Oncogene |volume=20 |issue= 18 |pages= 2197–204 |year= 2001 |pmid= 11402314 |doi= 10.1038/sj.onc.1204317
*cite journal | author=Wu C, Lai CF, Mobley WC |title=Nerve growth factor activates persistent Rap1 signaling in endosomes. |journal=J. Neurosci. |volume=21 |issue= 15 |pages= 5406–16 |year= 2001 |pmid= 11466412 |doi=
*cite journal | author=Yamasaki S, Nishida K, Hibi M, "et al." |title=Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules. |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 45175–83 |year= 2002 |pmid= 11572860 |doi= 10.1074/jbc.M105384200
*cite journal | author=Yamada K, Nishida K, Hibi M, "et al." |title=Comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and rat. |journal=Cytogenet. Cell Genet. |volume=94 |issue= 1-2 |pages= 39–42 |year= 2001 |pmid= 11701952 |doi=
*cite journal | author=Lynch DK, Daly RJ |title=PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2. |journal=EMBO J. |volume=21 |issue= 1-2 |pages= 72–82 |year= 2002 |pmid= 11782427 |doi=
*cite journal | author=Wheadon H, Paling NR, Welham MJ |title=Molecular interactions of SHP1 and SHP2 in IL-3-signalling. |journal=Cell. Signal. |volume=14 |issue= 3 |pages= 219–29 |year= 2002 |pmid= 11812650 |doi=
*cite journal | author=Dorsey JF, Cunnick JM, Mane SM, Wu J |title=Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl(+) K562 leukemic cells by Gab2. |journal=Blood |volume=99 |issue= 4 |pages= 1388–97 |year= 2002 |pmid= 11830491 |doi=
*cite journal | author=Hill RJ, Zozulya S, Lu YL, "et al." |title=The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation. |journal=Exp. Hematol. |volume=30 |issue= 3 |pages= 237–44 |year= 2002 |pmid= 11882361 |doi=
*cite journal | author=Yu WM, Hawley TS, Hawley RG, Qu CK |title=Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration. |journal=Blood |volume=99 |issue= 7 |pages= 2351–9 |year= 2002 |pmid= 11895767 |doi=

External links

* [http://news.bbc.co.uk/1/hi/health/6731227.stm Scientists find new dementia gene] - BBC News, 9 June 2007.

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