PEST sequence

PEST sequence

A PEST sequence is a peptide sequence which is rich in proline (P), glutamic acid (E), serine (S), and threonine (T). This sequence is associated with proteins that have a short intracellular half-life; hence, it is hypothesized that the PEST sequence acts as a signal peptide for protein degradation.[1]

The degradation may be mediated possibly via the proteosome[2][3] or calpain[4].

References

  1. ^ Rogers S, Wells R, Rechsteiner M (1986). "Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis". Science 234 (4774): 364–8. doi:10.1126/science.2876518. PMID 2876518. 
  2. ^ Reverte CG, Ahearn MD, Hake LE (2001). "CPEB degradation during Xenopus oocyte maturation requires a PEST domain and the 26S proteasome". Dev. Biol. 231 (2): 447–58. doi:10.1006/dbio.2001.0153. PMID 11237472. 
  3. ^ Spencer ML, Theodosiou M, Noonan DJ (2004). "NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif". J. Biol. Chem. 279 (35): 37069–78. doi:10.1074/jbc.M402507200. PMID 15229225. 
  4. ^ Shumway SD, Maki M, Miyamoto S (1999). "The PEST domain of IkappaBalpha is necessary and sufficient for in vitro degradation by mu-calpain". J. Biol. Chem. 274 (43): 30874–81. doi:10.1074/jbc.274.43.30874. PMID 10521480. 

Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • PEST sequence — (= Pro Glu Ser Thr) Amino acid motif that is thought to target cytoplasmic proteins for rapid proteolytic degradation …   Dictionary of molecular biology

  • CCNG1 — Cyclin G1, also known as CCNG1, is a human gene.cite web | title = Entrez Gene: CCNG1 cyclin G1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=900| accessdate = ] PBB Summary section title = summary text …   Wikipedia

  • BRDT — Bromodomain, testis specific, also known as BRDT, is a human gene.cite web | title = Entrez Gene: BRDT bromodomain, testis specific| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=676| accessdate = ] PBB… …   Wikipedia

  • Life Sciences — ▪ 2009 Introduction Zoology       In 2008 several zoological studies provided new insights into how species life history traits (such as the timing of reproduction or the length of life of adult individuals) are derived in part as responses to… …   Universalium

  • Crop rotation — Fallow redirects here. For other uses, see Fallow (disambiguation). Satellite image of circular crop fields in late June 2001. Healthy, growing crops are green. Corn would be growing into leafy stalks by then. Sorghum, which resembles corn, grows …   Wikipedia

  • Listeriolysin O — (LLO) is a hemolysin produced by the bacterium Listeria monocytogenes , the pathogen responsible for causing listeriosis. The toxin may be considered a virulence factor, since it is crucial for the virulence of L. monocytogenes . [cite journal… …   Wikipedia

  • PTPN12 — Protein tyrosine phosphatase, non receptor type 12, also known as PTPN12, is a human gene.cite web | title = Entrez Gene: PTPN12 protein tyrosine phosphatase, non receptor type 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • Glossary of environmental science — This is a glossary of environmental science.Environmental science is the study of interactions among physical, chemical, and biological components of the environment. Environmental science provides an integrated, quantitative, and… …   Wikipedia

  • evolution — evolutional, adj. evolutionally, adv. /ev euh looh sheuhn/ or, esp. Brit., /ee veuh /, n. 1. any process of formation or growth; development: the evolution of a language; the evolution of the airplane. 2. a product of such development; something… …   Universalium

  • Dingo — For other uses, see Dingo (disambiguation). Dingo Australian dingo Conservation status …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”