17-N-Allylamino-17-demethoxygeldanamycin
- 17-N-Allylamino-17-demethoxygeldanamycin
Chembox new
ImageFile = 17-N-Allylamino-17-demethoxygeldanamycin.svg
ImageSize =
IUPACName = [(3"S",5"S",6"R",7"S",8"E",10"R",11"S",12"E",14"E")-21-
(allylamino)-6-hydroxy-5,11-dimethoxy-3,
7,9,15-tetramethyl-16,20,22-trioxo-17-
azabicyclo [16.3.1] docosa-8,12,14,18,21-
pentaen-10-yl] carbamate
OtherNames =
Section1 = Chembox Identifiers
CASNo = 75747-14-7
PubChem = 6440175
ChemSpiderID = 21106220
SMILES = CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC
(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC
Section2 = Chembox Properties
Formula = C31H43N3O8
MolarMass = 585.689 g/mol
Appearance =
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MeltingPt =
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Section7 = Chembox Hazards
MainHazards =
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17-N-Allylamino-17-demethoxygeldanamycin is a substance that is being studied in the treatment of cancer, specific young patients with certain types of leukemia or solid tumors, especially kidney tumors. As of June 2005, 17-N-allylamino-17-demethoxygeldanamycin is undergoing Phase 1 and Phase 2 clinical trials. It belongs to the family of drugs called antitumor antibiotics.
References
External links
* [http://www.clinicaltrials.gov/ct/show/NCT00093821 Phase 1 trial ]
* [http://www.clinicaltrials.gov/ct/show/NCT00079404 Another Phase 1 trial]
* [http://www.nci.nih.gov/ncicancerbulletin/NCI_Cancer_Bulletin_021505/page6 National Cancer Institutie Bulletin on Phase 2 trials against Von Hippel-Lindau disease]
* [http://www.fermentek.co.il/MSDS/17AAG-MSDS.htm Safety sheet for 17AAG]
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