CBX1

Chromobox homolog 1 (HP1 beta homolog Drosophila ), also known as CBX1, is a human gene.cite web | title = Entrez Gene: CBX1 chromobox homolog 1 (HP1 beta homolog Drosophila )| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10951| accessdate = ]

PBB_Summary
section_title =
summary_text = Heterochromatin protein-1 (HP1) is localized at heterochromatin sites, where it mediates gene silencing. [supplied by OMIM] cite web | title = Entrez Gene: CBX1 chromobox homolog 1 (HP1 beta homolog Drosophila )| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10951| accessdate = ]

ee also

* Heterochromatin protein 1

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Furuta K, Chan EK, Kiyosawa K, "et al." |title=Heterochromatin protein HP1Hsbeta (p25beta) and its localization with centromeres in mitosis. |journal=Chromosoma |volume=106 |issue= 1 |pages= 11–9 |year= 1997 |pmid= 9169582 |doi=
*cite journal | author=Lessard J, Baban S, Sauvageau G |title=Stage-specific expression of polycomb group genes in human bone marrow cells. |journal=Blood |volume=91 |issue= 4 |pages= 1216–24 |year= 1998 |pmid= 9454751 |doi=
*cite journal | author=Aagaard L, Laible G, Selenko P, "et al." |title=Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. |journal=EMBO J. |volume=18 |issue= 7 |pages= 1923–38 |year= 1999 |pmid= 10202156 |doi= 10.1093/emboj/18.7.1923
*cite journal | author=Minc E, Allory Y, Worman HJ, "et al." |title=Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells. |journal=Chromosoma |volume=108 |issue= 4 |pages= 220–34 |year= 1999 |pmid= 10460410 |doi=
*cite journal | author=Murzina N, Verreault A, Laue E, Stillman B |title=Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins. |journal=Mol. Cell |volume=4 |issue= 4 |pages= 529–40 |year= 1999 |pmid= 10549285 |doi=
*cite journal | author=Nielsen AL, Ortiz JA, You J, "et al." |title=Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. |journal=EMBO J. |volume=18 |issue= 22 |pages= 6385–95 |year= 2000 |pmid= 10562550 |doi= 10.1093/emboj/18.22.6385
*cite journal | author=Brasher SV, Smith BO, Fogh RH, "et al." |title=The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer. |journal=EMBO J. |volume=19 |issue= 7 |pages= 1587–97 |year= 2000 |pmid= 10747027 |doi= 10.1093/emboj/19.7.1587
*cite journal | author=Zhao T, Heyduk T, Allis CD, Eissenberg JC |title=Heterochromatin protein 1 binds to nucleosomes and DNA in vitro. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 28332–8 |year= 2000 |pmid= 10882726 |doi= 10.1074/jbc.M003493200
*cite journal | author=Lachner M, O'Carroll D, Rea S, "et al." |title=Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. |journal=Nature |volume=410 |issue= 6824 |pages= 116–20 |year= 2001 |pmid= 11242053 |doi= 10.1038/35065132
*cite journal | author=Bannister AJ, Zegerman P, Partridge JF, "et al." |title=Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. |journal=Nature |volume=410 |issue= 6824 |pages= 120–4 |year= 2001 |pmid= 11242054 |doi= 10.1038/35065138
*cite journal | author=Nielsen AL, Oulad-Abdelghani M, Ortiz JA, "et al." |title=Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins. |journal=Mol. Cell |volume=7 |issue= 4 |pages= 729–39 |year= 2001 |pmid= 11336697 |doi=
*cite journal | author=Andersen JS, Lyon CE, Fox AH, "et al." |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=
*cite journal | author=Scholzen T, Endl E, Wohlenberg C, "et al." |title=The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure. |journal=J. Pathol. |volume=196 |issue= 2 |pages= 135–44 |year= 2002 |pmid= 11793364 |doi= 10.1002/path.1016
*cite journal | author=Nielsen PR, Nietlispach D, Mott HR, "et al." |title=Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9. |journal=Nature |volume=416 |issue= 6876 |pages= 103–7 |year= 2002 |pmid= 11882902 |doi= 10.1038/nature722
*cite journal | author=Vassallo MF, Tanese N |title=Isoform-specific interaction of HP1 with human TAFII130. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 9 |pages= 5919–24 |year= 2002 |pmid= 11959914 |doi= 10.1073/pnas.092025499
*cite journal | author=Hwang KK, Worman HJ |title=Gene regulation by human orthologs of Drosophila heterochromatin protein 1. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 4 |pages= 1217–22 |year= 2002 |pmid= 12054505 |doi= 10.1016/S0006-291X(02)00377-7
*cite journal | author=Bhattacharya N, Wang Z, Davitt C, "et al." |title=Pim-1 associates with protein complexes necessary for mitosis. |journal=Chromosoma |volume=111 |issue= 2 |pages= 80–95 |year= 2003 |pmid= 12111331 |doi= 10.1007/s00412-002-0192-6
*cite journal | author=Lin CY, Li CC, Huang PH, Lee FJ |title=A developmentally regulated ARF-like 5 protein (ARL5), localized to nuclei and nucleoli, interacts with heterochromatin protein 1. |journal=J. Cell. Sci. |volume=115 |issue= Pt 23 |pages= 4433–45 |year= 2003 |pmid= 12414990 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Festenstein R, Pagakis SN, Hiragami K, "et al." |title=Modulation of heterochromatin protein 1 dynamics in primary Mammalian cells. |journal=Science |volume=299 |issue= 5607 |pages= 719–21 |year= 2003 |pmid= 12560554 |doi= 10.1126/science.1078694

External links

*

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