Tre recombinase

Tre recombinase

Tre recombinase is an experimental enzyme that in lab tests has successfully removed DNA inserted by HIV from infected cells [Sarkar, I." et al." (2007): "HIV-1 proviral DNA excision using an evolved recombinase." In: "Science." Bd. 316, S. 1912-1915. PMID 17600219 DOI|10.1126/science.1141453] . The enzyme was derived from Cre recombinase through selective mutation for the purposes of identifying HIV markers, which are not bounded by loxP sites and therefore disallow attempts at Cre-Lox recombination.

References

External links

* [http://www.sciam.com/article.cfm?articleID=737AB56E-E7F2-99DF-382B756D1860EACA&chanID=sa003 Designer Enzyme Cuts HIV Out of Infected Cells]
* [http://www.physorg.com/news102261327.html Potential cure for HIV discovered] Dead link|date=June 2008
* [http://www.sciencemag.org/cgi/content/abstract/316/5833/1912 HIV-1 Proviral DNA Excision Using an Evolved Recombinase]


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