- Vital Brazil
:"For a place in
Rio de Janeiro, Brazil, see Vital Brazil, Brazil."
Vital Brazil Mineiro da Campanha, known as Vital Brazil (pron. IPA2|vitaw bɾaziw), (b.
April 28, 1865in Campanha, Minas Gerais, Brazil, d. May 8, 1950) was a Brazilian physician, biomedical scientistand immunologist, internationally renowned for the discovery of the polyvalent anti-ophidic serum used to treat bítes of venomous snakes of the " Crotalus", " Bothrops" and " Elaps" genera. He went on to be also the first to develop anti-scorpion and anti-spider serums. He was the founder of the Butantan Institute, a research center located in São Paulo, which was the first in the world dedicated exclusively to basic and applied toxicology, the science of venomous animals.
Vital Brazil was born on April 28, 1865, in the town of Campanha, in the state of Minas Gerais. His father gave him this curious name in homage to the country, the state and the city where he was born.
He graduated in
Medicinein 1891, in Rio de Janeiro, working as a technical assistant in the chair of Physiologyin order to pay for his tuition and living expenses. After graduating, he began work in public health, initially as a sanitary inspector in São Paulo (1892-1895), where he acquired experience in the prevalent epidemicdiseases of the time ( smallpox, typhoid fever, yellow feverand cholera), and then as a private practitioner in the city of Botucatu, from 1895 to 1896.
Vital Brazil was attracted by
medical researchin the growing fields of bacteriology, virologyand immunologyat the end of the 19th century, which were being fueled by the great discoveries in Europe, by Louis Pasteur, Robert Koch, Paul Ehrlichand many others. He therefore returned to São Paulo in 1897 and accepted a position in the Instituto Bacteriológico de São Paulo("Bacteriological Institute of São Paulo"), under direction of the great Brazilian pathologist and epidemiologist Adolfo Lutz. There, he worked on the preparation of sera against several diseases, particularly bubonic plague, of which he fell gravely ill, fortunately surviving it.
Due to his outstanding work, the government of São Paulo founded a new Serum Therapy Institute in 1901 and gave its directorship to Vital Brazil. He also founded the Institute of Hygiene, Serum Therapy and Veterinary Medicine in the city of
Niterói, in 1919.
Vital Brazil carried out scientific travels to
Europein 1904 and 1914 and to 1925 to the United States. He continued working at the Butantan Institute for several decades until his retirement in 1919. He died on May 8, 1950, celebrated as one of the most important Brazilian scientists ever.
The new São Paulo Institute was built in a section of the city named Butantan, at the time a far-away place, near the Pinheiros river, a swampy, sparsely inhabited area. Under Vital Brazil, it soon became an energetic and exemplary research center in vaccines and sera of all kinds, which were produced locally for the
prophylaxisand treatment of tetanus, diphtheria, yellow fever, smallpoxand several zoonoses(diseases transmitted to humans by animals), such as the dreaded hydrophobia. The Institute came to be well known by his original nickname, the Butantan Institute, and is still active today.
Vital Brazil was convinced since his early work at Butantan that envenomations (poisoning by accidents with venomous animals, such as
snakes, scorpions, spiders and batrachia, then the cause of thousands of deaths in enormous rural Brazil, which teemed with such tropical beasts) could be fought with antisera, i.e., antibodies specifically produced for venoms which were proteinsor long-chain peptides. A French immunologist, Albert Calmette(1863–1933) had demonstrated this for the first time in 1892, by developing a monovalent serum to treat bites by the Indian cobra("Naja tripudians").
Vital Brazil thus began a series of experimental investigations, and in 1901 he was able to prove that monovalent sera against the Asiatic species were ineffective against South American snakes, and proceeded to develop his first monovalent sera against the most common envenomations in Brazil, those produced by the "Bothrops", "Crotalus" and "Elaps" genera (represented respectively by the
jararaca snake, the rattlesnake, and the coral snake). He found several clinical and biochemical similarities between bothropic and crotalic envonomations and so he was the first to achieve a polyvalent serum, i.e., simultaneously effective against both species, which represented a triumph over the stark mortality caused by these species in North, Central and South America. In a few decades, this mortality, which was higher than 25% to 20% of bitten people, fell to less than 2%.
Applying the same techniques (which involved gradual
immunizationof horses and sheepby administering small doses of venoms, and then extracting, purifying and freeze-dryingthe antibody portion from the blood of injected animals), Vital Brazil and his coworkers were able to discover the first sera against two species of scorpions' (1908) and spiders' (1925) venoms. In the USA, Vital Brazil's name made the headlines when he used his serum to save the life of a worker in the Bronx Zooin New Yorkwho was bitten by a rattlesnake.
Most important of all, the Butantan Institute became a fertile school for breeding a new generation of Brazilian biochemists, physiologists and pathologists, such as
José Moura Gonçalves, Carlos Ribeiro Diniz, Gastão Rosenfeld, Wilson Teixeira Beraldoand Maurício Rocha e Silva, who went on to found a growing number of schools, departments and research laboratories in São Paulo, Rio de Janeiro and Minas Gerais, giving a great impetus to the development of medical and biological research and teaching in Brazil in the second half of the 20th century.
According to Argentinian
Nobel Prizewinner Bernardo Houssay, who wrote a well-cited biography of Vital Brazil in 1966, his contributions went further than herpetology:
"Vital Brazil and his collaborators have studied several actions of the venoms, (such as)
coagulant, anticoagulant, hemolytic, agglutinant, cytotoxic, proteolytic, etc. (...) The (animal) poisons contain numerous enzymes which have been isolated and studied with interest in all parts since they explain many of the symptomsand constitute interesting biochemical reagents, Vital Brazil studied also the ophiophagous serpents, such as the mussurana, the ophiophagous mammals, such as the skunk-like "Conepatus chilensis" and others, the ophiophagous birds and certain spiders. (...) His book, "La défense contre l’ophidisme" published in French in 1914, attained international repercussion with three editions."
Science and Technology in Brazil
* [http://www.ivb.rj.gov.br/ Instituto Vital Brazil] Website.
* Houssay, B.A. [http://www2.prossiga.br/VitalBrazil/sobre/transcendence.htm Transcendence of Vital Brazil´s Work] . "Memórias do Instituto Butantan", São Paulo, v. 33, p. xiii-xvi, 1966.
* [http://www.butantan.gov.br/index2.htm Instituto Butantan] Website.
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1519249&dopt=Abstract Hawgood BJ. Pioneers of anti-venomous serotherapy: Dr Vital Brazil (1865-1950)] . "Toxicon." 1992 May-Jun;30(5-6):573-9.
* [http://www2.prossiga.br/VitalBrazil/ Biblioteca Virtual Vital Brazil] (In Portuguese).
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