Macrophage migration inhibitory factor

Macrophage migration inhibitory factor (glycosylation-inhibiting factor)
PDB rendering based on 1ca7.
Available structures PDB 1CA7, 1CGQ, 1GCZ, 1GD0, 1GIF, 1LJT, 1MIF, 1P1G, 2OOH, 2OOW, 2OOZ, 3B9S, 3CE4, 3DJH, 3DJI, 3HOF, 3IJG, 3IJJ, 3JSF, 3JSG, 3JTU, 3L5P, 3L5R, 3L5S, 3L5T, 3L5U, 3L5V
Identifiers
Symbols	MIF; GIF; GLIF; MMIF
External IDs	OMIM: 153620 MGI: 96982 HomoloGene: 55655 GeneCards: MIF Gene
EC number	5.3.2.1
Gene Ontology Molecular function • dopachrome isomerase activity • receptor binding • cytokine activity • cytokine receptor binding • protein binding • isomerase activity • chemoattractant activity • cell surface binding • phenylpyruvate tautomerase activity Cellular component • extracellular region • extracellular space • cytoplasm • cell surface Biological process • prostaglandin biosynthetic process • inflammatory response • cell surface receptor linked signaling pathway • cell proliferation • negative regulation of gene expression • positive regulation of protein kinase A signaling cascade • carboxylic acid metabolic process • positive regulation of B cell proliferation • positive regulation of peptidyl-serine phosphorylation • positive regulation of phosphorylation • regulation of macrophage activation • negative regulation of apoptosis • negative regulation of DNA damage response, signal transduction by p53 class mediator • innate immune response • positive regulation of fibroblast proliferation • positive regulation of cytokine secretion • positive regulation of peptidyl-tyrosine phosphorylation • positive chemotaxis • protein homotrimerization • positive regulation of ERK1 and ERK2 cascade • negative regulation of cell cycle arrest Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4282	17319
Ensembl	ENSG00000240972	ENSMUSG00000033307
UniProt	P14174	P34884
RefSeq (mRNA)	NM_002415.1	NM_010798.2
RefSeq (protein)	NP_002406.1	NP_034928.1
Location (UCSC)	Chr 22: 24.24 – 24.24 Mb	Chr 10: 75.32 – 75.32 Mb
PubMed search	[1]	[2]
This box: view · protein that in humans is encoded by the MIF gene.[1][2] Structure Macrophage migration inhibitory factor assembles into a trimer composed of three identical subunits. Each of these monomers contain two antiparallel alpha helices and a four-stranded beta sheet. The monomers surround a central channel with 3-fold rotational symmetry.[3][4] Enzymatic activity MIF contains two motifs with catalytic activity. The first is a 27 amino acid motif located at the N-terminus functions as a phenylpyruvate tautomerase that can catalyze the conversion of 2-carboxy-2,3-dihydroindole-5,6-quinone (dopachrome) into 5,6-dihydroxyindole-2-carboxylic acid (DHICA).[5][6] MIF also contains a Cys-Ala-Leu-Cys catalytic site between residues 57 and 60 that appears to function as a disulfide reductase.[7] Function This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation.[8][9][10] MIF plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids.[11][12][10] This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate a role in integrin signaling pathways.[13] It has also been shown[14] to induce changes in the heart during sepsis. Interactions Macrophage migration inhibitory factor has been reported to interact with: BNIPL,[15] CD74,[16][17][18][19][20] COPS5,[21] CXCR4.[22][23][24] Clinical significance MIF is an inflammatory mediator associated with rheumatoid arthritis (RA) severity.[25][26][27] Additionally, evidence suggests that there is a correlation between MIF production and metastatic potential in colorectal cancer.[28] References ^ Weiser WY, Temple PA, Witek-Giannotti JS, Remold HG, Clark SC, David JR (October 1989). "Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor". Proc. Natl. Acad. Sci. U.S.A. 86 (19): 7522–6. doi:10.1073/pnas.86.19.7522. PMC 298097. PMID 2552447. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=2552447.  ^ Kozak CA, Adamson MC, Buckler CE, Segovia L, Paralkar V, Wistow G (June 1995). "Genomic cloning of mouse MIF (macrophage inhibitory factor) and genetic mapping of the human and mouse expressed gene and nine mouse pseudogenes". Genomics 27 (3): 405–11. doi:10.1006/geno.1995.1070. PMID 7558020.  ^ Sun HW, Bernhagen J, Bucala R, Lolis E (May 1996). "Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor". Proc. Natl. Acad. Sci. U.S.A. 93 (11): 5191–6. PMC 39220. PMID 8643551. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=39220.  ^ Al-Abed Y, VanPatten S (January 2011). "MIF as a disease target: ISO-1 as a proof-of-concept therapeutic". Future Med Chem 3 (1): 45–63. doi:10.4155/fmc.10.281. PMID 21428825.  ^ Rosengren E, Bucala R, Aman P, Jacobsson L, Odh G, Metz CN, Rorsman H (January 1996). "The immunoregulatory mediator macrophage migration inhibitory factor (MIF) catalyzes a tautomerization reaction". Mol. Med. 2 (1): 143–9. PMC 2230029. PMID 8900542. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2230029.  ^ Veillat V, Carli C, Metz CN, Al-Abed Y, Naccache PH, Akoum A (December 2010). "Macrophage migration inhibitory factor elicits an angiogenic phenotype in human ectopic endometrial cells and triggers the production of major angiogenic factors via CD44, CD74, and MAPK signaling pathways". J. Clin. Endocrinol. Metab. 95 (12): E403–12. doi:10.1210/jc.2010-0417. PMID 20829186.  ^ Thiele M, Bernhagen J (2005). "Link between macrophage migration inhibitory factor and cellular redox regulation". Antioxid. Redox Signal. 7 (9-10): 1234–48. doi:10.1089/ars.2005.7.1234. PMID 16115028.  ^ Leng L, Bucala R (February 2006). "Insight into the biology of macrophage migration inhibitory factor (MIF) revealed by the cloning of its cell surface receptor". Cell Res. 16 (2): 162–8. doi:10.1038/sj.cr.7310022. PMID 16474429.  ^ Chen PF, Luo YL, Wang W, et al. (2010). "ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma". Mol. Med. 16 (9-10): 400–8. doi:10.2119/molmed.2009.00128. PMC 2935952. PMID 20485865. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2935952.  ^ a b Takahashi K, Koga K, Linge HM, Zhang Y, Lin X, Metz CN, Al-Abed Y, Ojamaa K, Miller EJ (2009). "Macrophage CD74 contributes to MIF-induced pulmonary inflammation". Respir. Res. 10: 33. doi:10.1186/1465-9921-10-33. PMC 2681459. PMID 19413900. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2681459.  ^ Flaster H, Bernhagen J, Calandra T, Bucala R (June 2007). "The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity". Mol. Endocrinol. 21 (6): 1267–80. doi:10.1210/me.2007-0065. PMID 17389748.  ^ Al-Abed Y, Metz CN, Cheng KF, et al. (May 2011). "Thyroxine is a potential endogenous antagonist of macrophage migration inhibitory factor (MIF) activity". Proc. Natl. Acad. Sci. U.S.A. 108 (20): 8224–7. doi:10.1073/pnas.1017624108. PMID 21536912.  ^ "Entrez Gene: MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4282.  ^ Lin X, Sakuragi T, Metz CN, Ojamaa K, Skopicki HA, Wang P, Al-Abed Y, Miller EJ (December 2005). "Macrophage migration inhibitory factor within the alveolar spaces induces changes in the heart during late experimental sepsis". Shock 24 (6): 556–63. doi:10.1097/01.shk.0000183238.70374.a8. PMID 16317387.  ^ Shen L, Hu J, Lu H, Wu M, Qin W, Wan D, Li YY, Gu J (April 2003). "The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER". FEBS Lett. 540 (1–3): 86–90. doi:10.1016/S0014-5793(03)00229-1. PMID 12681488.  ^ Leng L, Metz CN, Fang Y, Xu J, Donnelly S, Baugh J, Delohery T, Chen Y, Mitchell RA, Bucala R (June 2003). "MIF signal transduction initiated by binding to CD74". J. Exp. Med. 197 (11): 1467–76. doi:10.1084/jem.20030286. PMC 2193907. PMID 12782713. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193907.  ^ Bacher M, Deuster O, Aljabari B, et al. (March 2010). "The role of macrophage migration inhibitory factor in Alzheimer's disease". Mol. Med. 16 (3-4): 116–21. doi:10.2119/molmed.2009.00123. PMC 2829616. PMID 20200619. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2829616.  ^ Shan ZX, Lin QX, Deng CY, Tan HH, Kuang SJ, Xiao DZ, Zhu JN, Fu YH, Yu XY (December 2009). "[Identification of the interactions between the truncated fragments of macrophage migration inhibitory factor and CD74 using a yeast two-hybrid system]" (in Chinese). Nan Fang Yi Ke Da Xue Xue Bao 29 (12): 2383–6, 2390. PMID 20034881.  ^ Wang F, Shen X, Guo X, Peng Y, Liu Y, Xu S, Yang J (February 2010). "Spinal macrophage migration inhibitory factor contributes to the pathogenesis of inflammatory hyperalgesia in rats". Pain 148 (2): 275–83. doi:10.1016/j.pain.2009.11.011. PMID 20005040.  ^ Dobson SE, Augustijn KD, Brannigan JA, Schnick C, Janse CJ, Dodson EJ, Waters AP, Wilkinson AJ (December 2009). "The crystal structures of macrophage migration inhibitory factor from Plasmodium falciparum and Plasmodium berghei". Protein Sci. 18 (12): 2578–91. doi:10.1002/pro.263. PMC 2798171. PMID 19827093. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2798171.  ^ Kleemann R, Hausser A, Geiger G, Mischke R, Burger-Kentischer A, Flieger O, Johannes FJ, Roger T, Calandra T, Kapurniotu A, Grell M, Finkelmeier D, Brunner H, Bernhagen J (November 2000). "Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1". Nature 408 (6809): 211–6. doi:10.1038/35041591. PMID 11089976.  ^ Schwartz V, Lue H, Kraemer S, Korbiel J, Krohn R, Ohl K, Bucala R, Weber C, Bernhagen J (September 2009). "A functional heteromeric MIF receptor formed by CD74 and CXCR4". FEBS Lett. 583 (17): 2749–57. doi:10.1016/j.febslet.2009.07.058. PMID 19665027.  ^ Schrader J, Deuster O, Rinn B, et al. (2009). "Restoration of contact inhibition in human glioblastoma cell lines after MIF knockdown". BMC Cancer 9: 464. doi:10.1186/1471-2407-9-464. PMC 2810303. PMID 20038293. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2810303.  ^ Stosic-Grujicic S, Stojanovic I, Maksimovic-Ivanic D, Momcilovic M, Popadic D, Harhaji L, Miljkovic D, Metz C, Mangano K, Papaccio G, Al-Abed Y, Nicoletti F (June 2008). "Macrophage migration inhibitory factor (MIF) is necessary for progression of autoimmune diabetes mellitus". J. Cell. Physiol. 215 (3): 665–75. doi:10.1002/jcp.21346. PMID 18064633.  ^ Bifulco C, McDaniel K, Leng L, Bucala R (2008). "Tumor growth-promoting properties of macrophage migration inhibitory factor". Curr. Pharm. Des. 14 (36): 3790–801. PMID 19128232.  ^ Carli C, Metz CN, Al-Abed Y, Naccache PH, Akoum A (July 2009). "Up-regulation of cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic cells by macrophage migration inhibitory factor: involvement of novel kinase signaling pathways". Endocrinology 150 (7): 3128–37. doi:10.1210/en.2008-1088. PMC 2703510. PMID 19299454. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2703510.  ^ Lue H, Kleemann R, Calandra T, Roger T, Bernhagen J (April 2002). "Macrophage migration inhibitory factor (MIF): mechanisms of action and role in disease". Microbes Infect. 4 (4): 449–60. doi:10.1016/S1286-4579(02)01560-5. PMID 11932196.  ^ He XX, Chen K, Yang J, Li XY, Gan HY, Liu CY, Coleman TR, Al-Abed Y (2009). "Macrophage migration inhibitory factor promotes colorectal cancer". Mol. Med. 15 (1-2): 1–10. doi:10.2119/molmed.2008.00107. PMC 2581606. PMID 19009023. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2581606.  Further reading Bondza PK, Metz CN, Akoum A (April 2008). "Macrophage migration inhibitory factor up-regulates alpha(v)beta(3) integrin and vascular endothelial growth factor expression in endometrial adenocarcinoma cell line Ishikawa". J. Reprod. Immunol. 77 (2): 142–51. doi:10.1016/j.jri.2007.07.004. PMID 17854909.  Larson DF, Horak K (2006). "Macrophage migration inhibitory factor: controller of systemic inflammation". Critical care (London, England) 10 (2): 138. doi:10.1186/cc4899. PMC 1550887. PMID 16677407. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1550887.  Akoum A, Metz CN, Al-Akoum M, Kats R (May 2006). "Macrophage migration inhibitory factor expression in the intrauterine endometrium of women with endometriosis varies with disease stage, infertility status, and pelvic pain". Fertil. Steril. 85 (5): 1379–85. doi:10.1016/j.fertnstert.2005.10.073. PMID 16616746.  Calandra T, Roger T (2003). "Macrophage migration inhibitory factor: a regulator of innate immunity". Nat. Rev. Immunol. 3 (10): 791–800. doi:10.1038/nri1200. PMID 14502271.  Shimizu T (2005). "Role of macrophage migration inhibitory factor (MIF) in the skin". J. Dermatol. Sci. 37 (2): 65–73. doi:10.1016/j.jdermsci.2004.08.007. PMID 15659324.  Ouertatani-Sakouhi H, Liu M, El-Turk F, Cuny GD, Glicksman MA, Lashuel HA (April 2010). "Kinetic-based high-throughput screening assay to discover novel classes of macrophage migration inhibitory factor inhibitors". Journal of Biomolecular Screening : the Official Journal of the Society for Biomolecular Screening 15 (4): 347–58. doi:10.1177/1087057110363825. PMID 20231420.  Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Sant'Emidio alla Grotte 1998–99 New Jersey Devils season Look at other dictionaries: migration inhibitory factor — Factor that inhibits macrophage movement. 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