- Liver receptor homolog-1
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The liver receptor homolog-1 (LRH-1) also known as NR5A2 (nuclear receptor subfamily 5, group A, member 2) is a protein that in humans is encoded by the NR5A2 gene.[1][2] LRH-1 is a member of the nuclear receptor family of intracellular transcription factors.
LRH-1 plays a critical role in the regulation of development, cholesterol transport, bile acid homeostasis and steroidogenesis.[3]
Contents
Interactions
Liver receptor homolog-1 has been shown to interact with the small heterodimer partner.[4][5]
References
- ^ Bernier D, Thomassin H, Allard D, et al. (1993). "Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer". Mol. Cell. Biol. 13 (3): 1619–33. PMC 359474. PMID 7680097. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=359474.
- ^ Galarneau L, Drouin R, Bélanger L (1998). "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization". Cytogenet. Cell Genet. 82 (3–4): 269–70. doi:10.1159/000015116. PMID 9858833.
- ^ Fayard E, Auwerx J, Schoonjans K (2004). "LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis". Trends Cell Biol. 14 (5): 250–60. doi:10.1016/j.tcb.2004.03.008. PMID 15130581.
- ^ Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J (September 2002). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Mol. Endocrinol. 16 (9): 2065–76. doi:10.1210/me.2001-0194. PMID 12198243.
- ^ Lee YK, Moore DD (January 2002). "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". J. Biol. Chem. 277 (4): 2463–7. doi:10.1074/jbc.M105161200. PMID 11668176.
Further reading
- Wong M, Ramayya MS, Chrousos GP, et al. (1997). "Cloning and sequence analysis of the human gene encoding steroidogenic factor 1". J. Mol. Endocrinol. 17 (2): 139–47. doi:10.1677/jme.0.0170139. PMID 8938589.
- Li M, Xie YH, Kong YY, et al. (1998). "Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus". J. Biol. Chem. 273 (44): 29022–31. doi:10.1074/jbc.273.44.29022. PMID 9786908.
- Nitta M, Ku S, Brown C, et al. (1999). "CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7α-hydroxylase gene". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6660–5. doi:10.1073/pnas.96.12.6660. PMC 21971. PMID 10359768. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21971.
- Goodwin B, Jones SA, Price RR, et al. (2000). "A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis". Mol. Cell 6 (3): 517–26. doi:10.1016/S1097-2765(00)00051-4. PMID 11030332.
- Wang ZN, Bassett M, Rainey WE (2001). "Liver receptor homologue-1 is expressed in the adrenal and can regulate transcription of 11 beta-hydroxylase". J. Mol. Endocrinol. 27 (2): 255–8. doi:10.1677/jme.0.0270255. PMID 11564608.
- Zhang CK, Lin W, Cai YN, et al. (2001). "Characterization of the genomic structure and tissue-specific promoter of the human nuclear receptor NR5A2 (hB1F) gene". Gene 273 (2): 239–49. doi:10.1016/S0378-1119(01)00586-8. PMID 11595170.
- Lee YK, Moore DD (2002). "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". J. Biol. Chem. 277 (4): 2463–7. doi:10.1074/jbc.M105161200. PMID 11668176.
- Clyne CD, Speed CJ, Zhou J, Simpson ER (2002). "Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes". J. Biol. Chem. 277 (23): 20591–7. doi:10.1074/jbc.M201117200. PMID 11927588.
- Brendel C, Gelman L, Auwerx J (2003). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. doi:10.1210/me.16.6.1367. PMID 12040021.
- Sirianni R, Seely JB, Attia G, et al. (2002). "Liver receptor homologue-1 is expressed in human steroidogenic tissues and activates transcription of genes encoding steroidogenic enzymes". J. Endocrinol. 174 (3): R13–7. doi:10.1677/joe.0.174R013. PMID 12208674.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA (2003). "Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1". Mol. Cell 11 (6): 1575–85. doi:10.1016/S1097-2765(03)00236-3. PMID 12820970.
- Privalsky ML (2003). "Activation incarnate". Dev. Cell 5 (1): 1–2. doi:10.1016/S1534-5807(03)00196-5. PMID 12852843.
- Fayard E, Schoonjans K, Annicotte JS, Auwerx J (2003). "Liver receptor homolog 1 controls the expression of carboxyl ester lipase". J. Biol. Chem. 278 (37): 35725–31. doi:10.1074/jbc.M302370200. PMID 12853459.
- Annicotte JS, Fayard E, Swift GH, et al. (2003). "Pancreatic-Duodenal Homeobox 1 Regulates Expression of Liver Receptor Homolog 1 during Pancreas Development". Mol. Cell. Biol. 23 (19): 6713–24. doi:10.1128/MCB.23.19.6713-6724.2003. PMC 193920. PMID 12972592. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=193920.
- Peng N, Kim JW, Rainey WE, et al. (2004). "The role of the orphan nuclear receptor, liver receptor homologue-1, in the regulation of human corpus luteum 3beta-hydroxysteroid dehydrogenase type II". J. Clin. Endocrinol. Metab. 88 (12): 6020–8. doi:10.1210/jc.2003-030880. PMID 14671206.
- Cai YN, Zhou Q, Kong YY, et al. (2004). "LRH-1/hB1F and HNF1 synergistically up-regulate hepatitis B virus gene transcription and DNA replication". Cell Res. 13 (6): 451–8. doi:10.1038/sj.cr.7290187. PMID 14728801.
- Saxena D, Safi R, Little-Ihrig L, Zeleznik AJ (2004). "Liver receptor homolog-1 stimulates the progesterone biosynthetic pathway during follicle-stimulating hormone-induced granulosa cell differentiation". Endocrinology 145 (8): 3821–9. doi:10.1210/en.2004-0423. PMID 15117876.
External links
PDB gallery 
1yok: crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol
1yuc: Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, Bound to Phospholipid and a Fragment of Human SHP
1zdu: The Crystal Structure of Human Liver Receptor Homologue-1
2a66: Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
2ff0: Solution Structure of Steroidogenic Factor 1 DNA Binding Domain Bound to its Target Sequence in the Inhibin alpha-subunit PromoterTranscription factors and intracellular receptors (1) Basic domains (1.1) Basic leucine zipper (bZIP)Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) · AP-1 (c-Fos, FOSB, FOSL1, FOSL2, JDP2, c-Jun, JUNB, JUND) · BACH (1, 2) · BATF · BLZF1 · C/EBP (α, β, γ, δ, ε, ζ) · CREB (1, 3, L1) · CREM · DBP · DDIT3 · GABPA · HLF · MAF (B, F, G, K) · NFE (2, L1, L2, L3) · NFIL3 · NRL · NRF (1, 2, 3) · XBP1(1.2) Basic helix-loop-helix (bHLH)ATOH1 · AhR · AHRR · ARNT · ASCL1 · BHLHB2 · BMAL (ARNTL, ARNTL2) · CLOCK · EPAS1 · FIGLA · HAND (1, 2) · HES (5, 6) · HEY (1, 2, L) · HES1 · HIF (1A, 3A) · ID (1, 2, 3, 4) · LYL1 · MESP2 · MXD4 · MYCL1 · MYCN · Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) · Neurogenins (1, 2, 3) · NeuroD (1, 2) · NPAS (1, 2, 3) · OLIG (1, 2) · Pho4 · Scleraxis · SIM (1, 2) · TAL (1, 2) · Twist · USF1(1.3) bHLH-ZIP(1.4) NF-1(1.5) RF-X(1.6) Basic helix-span-helix (bHSH)(2) Zinc finger DNA-binding domains (2.1) Nuclear receptor (Cys4)subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR)
subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX)
subfamily 3 (Steroid hormone (Androgen, Estrogen (α, β), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related (α, β, γ))
subfamily 4 NUR (NGFIB, NOR1, NURR1) · subfamily 5 (LRH-1, SF1) · subfamily 6 (GCNF) · subfamily 0 (DAX1, SHP)(2.2) Other Cys4(2.3) Cys2His2General transcription factors (TFIIA, TFIIB, TFIID, TFIIE (1, 2), TFIIF (1, 2), TFIIH (1, 2, 4, 2I, 3A, 3C1, 3C2))
ATBF1 · BCL (6, 11A, 11B) · CTCF · E4F1 · EGR (1, 2, 3, 4) · ERV3 · GFI1 · GLI-Krüppel family (1, 2, 3, REST, S2, YY1) · HIC (1, 2) · HIVEP (1, 2, 3) · IKZF (1, 2, 3) · ILF (2, 3) · KLF (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17) · MTF1 · MYT1 · OSR1 · PRDM9 · SALL (1, 2, 3, 4) · SP (1, 2, 4, 7, 8) · TSHZ3 · WT1 · Zbtb7 (7A, 7B) · ZBTB (16, 17, 20, 32, 33, 40) · zinc finger (3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 300, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 644, 649, 655)(2.4) Cys6(2.5) Alternating composition(3) Helix-turn-helix domains (3.1) HomeodomainARX · CDX (1, 2) · CRX · CUTL1 · DBX (1, 2) · DLX (3, 4, 5) · EMX2 · EN (1, 2) · FHL (1, 2, 3) · HESX1 · HHEX · HLX · Homeobox (A1, A2, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C12, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) · HOPX · IRX (1, 2, 3, 4, 5, 6, MKX) · LMX (1A, 1B) · MEIS (1, 2) · MEOX2 · MNX1 · MSX (1, 2) · NANOG · NKX (2-1, 2-2, 2-3, 2-5, 3-1, 3-2, 6-1, 6-2) · NOBOX · PBX (1, 2, 3) · PHF (1, 3, 6, 8, 10, 16, 17, 20, 21A) · PHOX (2A, 2B) · PITX (1, 2, 3) · POU domain (PIT-1, BRN-3: A, B, C, Octamer transcription factor: 1, 2, 3/4, 6, 7, 11) · OTX (1, 2) · PDX1 · SATB2 · SHOX2 · VAX1 · ZEB (1, 2)(3.2) Paired box(3.3) Fork head / winged helix(3.4) Heat Shock Factors(3.5) Tryptophan clusters(3.6) TEA domain(4) β-Scaffold factors with minor groove contacts (4.1) Rel homology region(4.2) STAT(4.3) p53(4.4) MADS box(4.6) TATA binding proteins(4.7) High-mobility group(4.10) Cold-shock domainCSDA, YBX1(4.11) Runt(0) Other transcription factors (0.2) HMGI(Y)(0.3) Pocket domain(0.6) MiscellaneousCategories:- Human proteins
- Chromosome 1 gene stubs
- Intracellular receptors
- Transcription factors
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