Anticalin

Anticalin

Anticalin is a new generation of therapeutic protein products, synthesized from human lipocalins which are a family of naturally binding proteins. Anticalins are being used in lieu of monoclonal antibodies, the physicochemical properties being the same except for differences in their molecular weight, the former having a size of about 20kDa.

tructure

Characteristic for Anticalins is their barrel structure formed by eight antiparallel β-strands pairwise connected by loops and an attached α-helix.The main structure of Anticalins is identical to wild type lipocalins. Conformational deviations are primarily located in the four loops reaching in the ligand binding site. [Bachelor Thesis: " [http://www.entaja.de/anticalin.pdf Effect of Enzyme and Ligand Protonation on the Binding of Fluorescein to Anticalin] "]

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