- CARM1
protein
Name = coactivator-associated arginine methyltransferase 1
caption =
width =
HGNCid = 23393
Symbol = CARM1
AltSymbols =
EntrezGene = 10498
OMIM = 603934
RefSeq = XM_032719
UniProt = Q86X55
PDB =
ECnumber = 2.1.1.125
Chromosome = 19
Arm = p
Band = 13.2
LocusSupplementaryData = protein
Name = coactivator associated arginine methyltransferase 1-like
caption =
width =
HGNCid = 23392
Symbol = CARM1L
AltSymbols =
EntrezGene = 256280
OMIM =
RefSeq = XM_171224
UniProt = Q5SZY8
PDB =
ECnumber =
Chromosome = 9
Arm = p
Band = 24.2
LocusSupplementaryData =CARM1 (coactivator-associated arginine methyltransferase 1) is an
enzyme (EC number|2.1.1.125) encoded by the gene|CARM1 gene found in human beings, as well as many other mammals.cite journal | author = Chen D, Ma H, Hong H, Koh SS, Huang SM, Schurter BT, Aswad DW, Stallcup MR | title = Regulation of transcription by a protein methyltransferase | journal = Science | volume = 284 | issue = 5423 | pages = 2174–7 | year = 1999 | pmid = 10381882 | doi = 10.1126/science.284.5423.2174 | issn = ] CARM1 is a secondary coactivator through its association with p160 family (SRC-1 ,GRIP1 , AIB) of coactivators. It is responsible for moving cells toward the inner cell mass in developing blastocysts.cite journal | author = Torres-Padilla ME, Parfitt DE, Kouzarides T, Zernicka-Goetz M | title = Histone arginine methylation regulates pluripotency in the early mouse embryo | journal = Nature | volume = 445 | issue = 7124 | pages = 214–8 | year = 2007 | pmid = 17215844 | doi = 10.1038/nature05458 | issn = ] This gene also plays an important role in androgen receptors and may play a role in prostate cancer progression.cite journal | author = Hong H, Kao C, Jeng MH, Eble JN, Koch MO, Gardner TA, Zhang S, Li L, Pan CX, Hu Z, MacLennan GT, Cheng L | title = Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status | journal = Cancer | volume = 101 | issue = 1 | pages = 83–9 | year = 2004 | pmid = 15221992 | doi = 10.1002/cncr.20327 | issn = ] cite journal | author = Majumder S, Liu Y, Ford OH, Mohler JL, Whang YE | title = Involvement of arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability | journal = Prostate | volume = 66 | issue = 12 | pages = 1292–301 | year = 2006 | pmid = 16705743 | doi = 10.1002/pros.20438 | issn = ]ee also
* histone-arginine N-methyltransferase
External links
*
*References
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