Small Cajal body-specific RNA
- Small Cajal body-specific RNA
Small Cajal body-specific RNAs (scaRNAs) are a class of small nucleolar RNAs (snoRNAs) which specifically localise to the Cajal body, a nuclear organelle involved in the biogenesis of small nuclear ribonucleoproteins (snRNPs or snurps). ScaRNAs guide the modification (methylation and pseudouridylation) of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.
The first scaRNA identified was U85 [cite journal | author = Jády BE, Kiss T | title = A small nucleolar guide RNA functions both in 2'-O-ribose methylation and pseudouridylation of the U5 spliceosomal RNA | journal = Embo J. | volume = 20 | issue = 3 | pages = 541–51 | year = 2001 | pmid = 11157760 | doi = 10.1093/emboj/20.3.541 ] . It is unlike typical snoRNAs in that it is a composite C/D box and H/ACA box snoRNAs and can guide both pseudouridylation and 2'-O-methylation. Not all scaRNAs are composite C/D and H/ACA box snoRNA and most scaRNAs are structurally and functionally indistinguishable from snoRNAs directing ribosomal RNA (rRNA) modification in the nucleolus.]mall Cajal body-specific RNA 1
In molecular biology, Small Cajal body specific RNA 1 (also known as "scaRNA1" or "ACA35") is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U2 spliceosomal RNA.
scaRNA1 is a non-coding RNA, which are functional products of gene but not translated into a protein. Such RNA molecules usually contain important secondary structure or ligand binding motifs and are involved in many important biological processes in the cell. More specifically, scaRNAs are a class of small nuclear RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[cite journal | last = Darzacq | first = X | coauthors = Jady BE, Verheggen C, Kiss AM, Bertrand E, Kiss T | year = 2002 | title = Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs | journal = EMBO J. | volume = 21 | pages = 2746–2756 | pmid = 12032087 | doi = 10.1093/emboj/21.11.2746] ]scaRNA1 belongs to the H/ACA box class of guide RNAs, as it has the predicted hairpin-hinge-hairpin-tail structure, conserved H/ACA-box motifs and is found associated with GAR1 protein.[cite journal | last = Kiss | first = AM | coauthors = Jady BE, Bertrand E, Kiss T | year = 2004 | title = Human box H/ACA pseudouridylation guide RNA machinery | journal = Mol Cell Biol. | volume = 24 | pages = 5797–5807 | pmid = 15199136 | doi = 10.1128/MCB.24.13.5797-5807.2004] It is predicted to guide pseudouridylation of the U2 spliceosomal RNA at residue U89.]External links
* [http://www-snorna.biotoul.fr/info.php#4 snoRNAbase: human H/ACA and C/D box snoRNA database]
References
Wikimedia Foundation.
2010.
Look at other dictionaries:
Small Cajal body specific RNA 6 — (also known as SCARNA6 or U88) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U5 spliceosomal RNA.scaRNAs are a specific class of small nucleolar… … Wikipedia
Small Cajal body specific RNA 23 — (also known as SCARNA23 or ACA11) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U1 spliceosomal RNA.scaRNAs are a specific class of small… … Wikipedia
Small Cajal body specific RNA 15 — (also known as SCARNA15 or ACA45) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U1 spliceosomal RNA.scaRNAs are a specific class of small… … Wikipedia
Small Cajal body specific RNA 16 — (also known as SCARNA16 or ACA47) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U1 spliceosomal RNA.scaRNAs are a specific class of small… … Wikipedia
Small Cajal body specific RNA 24 — (also known as scaRNA24 or ACA12) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U6 spliceosomal RNA.scaRNAs are a specific class of small… … Wikipedia
Small Cajal body specific RNA 8 — (also known as SCARNA8 or U92) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U2 spliceosomal RNA.scaRNAs are a specific class of small nucleolar… … Wikipedia
Small Cajal body-specific RNA 18 — (also known as U91 or U4 8) is a type of small nuclear RNA which localises to the cajal bodies and proposed to guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12cite journal | author = Darzacq X, Jády … Wikipedia
Small Cajal body specific RNA 25 — (otherwise known as scaRNA25, HBI 100, MBI 100 and MBI 114) is a scaRNA which are a class of ncRNAs characterised as a small nuclear RNAs localised to the Cajal bodies [cite journal | last = Darzacq | first = X | coauthors = Jady BE, Verheggen C … Wikipedia
Small Cajal body specific RNA 13 — In molecular biology, Small Cajal body specific RNA 13 (also known as scaRNA13 or U93) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U2 and U5 spliceosomal RNA. scaRNAs are a specific class … Wikipedia
Small Cajal body specific RNA 20 — In molecular biology, Small Cajal body specific RNA 20 (also known as scaRNA20 or ACA66) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U12 minor spliceosomal RNA. scaRNAs are a specific… … Wikipedia
