Bromopride

drugbox
IUPAC_name = 4-amino-5-bromo-"N"-(2-diethylaminoethyl)-
2-methoxybenzamide

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CAS_number = 4093-35-0
ChemSpiderID = 2352
ATC_prefix = A03
ATC_suffix = FA04
PubChem = 2446
DrugBank =
C = 14 | H = 22 | Br = 1 | N = 3 | O = 2
molecular_weight = 344.248 g/mol
bioavailability = 50 to 75% (oral)
78% (intramuscular)
protein_bound = 40%
metabolism = Hepatic
elimination_half-life = 4 to 5 hours
excretion = Renal, 10 to 14% unchanged
pregnancy_AU =
pregnancy_US =
pregnancy_category =
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status = Red Label (BR)
routes_of_administration = Oral, IM, IV

Bromopride (INN) is a dopamine antagonist with prokinetic properties widely used as an antiemetic, closely related to metoclopramide. It is not available in the United States.

Bromopride appears to be safe and effective for use in pregnancy. [cite journal | author = Araújo JR | title = Evaluation of bromopride in nausea and vomiting of pregnancy | language = Portuguese | journal = J Bras Ginecol | year = 1981 | volume = 91 | issue = 4 | pages = 283–5]

Indications

Bromopride is indicated in the treatment of nausea and vomiting, including postoperative nausea and vomiting (PONV); gastroesophageal reflux disease (GERD/GORD); and as preparation for endoscopy and radiographic studies of the gastrointestinal tract. The manufacturer also claims it is valuable in, among other indications, hiccups and gastrointestinal adverse effects of radiation therapy.

Adverse effects

Bromopride is generally well tolerated; the most common adverse effects of its use are somnolence and fatigue. Bromopride may rarely cause extrapyramidal symptoms and, as metoclopramide, may increase prolactin levels. [cite web | url = http://bulario.bvs.br/index.php?action=search.2004031716564761099966000112&mode=dir&letter=B | title = Bula do Profissional de Saúde: Bromoprida | date = April 11 2006 | accessdate = 2007-07-23 | publisher = Brazilian National Health Surveillance Agency | work = Bulário Eletrônico da Anvisa | language = Portuguese]

Chemistry

Bromopride is a substituted benzamide, closely related to metoclopramide. [cite journal |author=Brodie RR, Chasseaud LF, Darragh A, Lambe RF, Rooney L, Taylor T |title=Pharmacokinetics and bioavailability of the anti-emetic agent bromopride |journal=Biopharm Drug Dispos |volume=7 |issue=3 |pages=215–22 |year=1986 |pmid=3730521 |doi=10.1002/bdd.2510070302] It is identical to metoclopramide except for the presence of a bromine atom where metoclopramide has a chlorine substituent.

Availability

Bromopride is not available in the United States or the United Kingdom. It is marketed in Brazil by Sanofi-Synthélabo under the trade name Digesan and as a generic drug.

References