Anti-sp100 antibodies

Anti-sp100 antibodies are found in association with primary biliary cirrhosis.cite journal | author = Szostecki C, Guldner HH, Netter HJ, Will H | title = Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis | journal = J. Immunol. | volume = 145 | issue = 12 | pages = 4338–47 | year = 1990 | pmid = 2258622 | doi = ] The autoimmune target of anti-sp100 is the sp100 nuclear antigen which was identified by its association with primary biliary cirrhosis. 20-30% of patients suffering from primary biliary cirrhosis sp100 Abs.

=Immunodominant regions of sp100=
* antigenic region 1 - positions 296-311 - Sequence (I K K E K P F S N S K V E C Q A)
* antigenic region 2 - positions 332-351 - Sequence (E G S T D V D E P L E V F I S A P R S E)(Bolded areas represent the core epitope)cite journal | author = Blüthner M, Schäfer C, Schneider C, Bautz FA | title = Identification of major linear epitopes on the sp100 nuclear PBC autoantigen by the gene-fragment phage-display technology | journal = Autoimmunity | volume = 29 | issue = 1 | pages = 33–42 | year = 1999 | pmid = 10052683 | doi = ]

=References=