Etofibrate

Etofibrate

drugbox
IUPAC_name = 2-{ [2-(4-chlorophenoxy)-2-methylpropanoyl] oxy}ethyl nicotinate



CAS_number = 31637-97-5
ATC_prefix = C10
ATC_suffix = AB09
PubChem = 65777
DrugBank =
C=18|H=18|Cl=1|N=1|O=5
molecular_weight = 363.792 g/mol
bioavailability =
protein_bound =
metabolism = Hydrolyzed to clofibric acid and niacin
elimination_half-life =
excretion =
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status =
routes_of_administration =

Etofibrate is a fibrate. It is a combination of clofibrate and niacin, linked together by an ester bond. In the body, clofibrate and niacin separate and are released gradually, in a manner similar to controlled-release formulations. [cite journal |author=Sposito AC, Mansur AP, Maranhão RC, Rodrigues-Sobrinho CR, Coelho OR, Ramires JA |title=Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects |journal=Braz J Med Biol Res |volume=34 |issue=2 |pages=177–82 |year=2001 |pmid=11175492 |doi= [http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000200004 Free full text] ]

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