Benfluorex

drugbox
IUPAC_name = 2- [1- [3-(trifluoromethyl)phenyl] propan-2-ylamino]
ethyl benzoate

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CAS_number = 23602-78-0
ChemSpiderID = 2228
ATC_prefix = C10
ATC_suffix = AX04
PubChem = 2318
DrugBank =
C=19|H=20|F=3|N=1|O=2
molecular_weight = 351.363 g/mol
bioavailability =
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elimination_half-life =
excretion = Renal
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routes_of_administration = Oral

Benfluorex is an anorectic and hypolipidemic agent. Clinical studies have shown it may improve glycemic control and decrease insulin resistance in people with poorly controlled type 2 diabetes; [cite journal |author=Moulin P, Andre M, Alawi H, "et al" |title=Efficacy of benfluorex in combination with sulfonylurea in type 2 diabetic patients: an 18-week, randomized, double-blind study |journal=Diabetes Care |volume=29 |issue=3 |pages=515–20 |year=2006 |pmid=16505498 |doi= [http://care.diabetesjournals.org/cgi/content/full/29/3/515 Free full text] ] [cite journal |author=Roger P, Auclair J, Drain P |title=Addition of benfluorex to biguanide improves glycemic control in obese non-insulin-dependent diabetes: a double-blind study versus placebo |journal=J Diabetes Complications |volume=13 |issue=2 |pages=62–7 |year=1999 |pmid=10432168 |doi=] it is marketed in France as an adjuvant antidiabetic.

Benfluorex is structurally related to fenfluramine.

References