Beta-lactamase inhibitor

Beta-lactamase inhibitor

A beta-lactamase inhibitor is a drug given in conjunction with a beta-lactam antibiotic. Although the inhibitor does not usually have significant antibiotic activity on its own, [cite web |url=http://www.fhsu.edu/nursing/otitis/bl_inhibit.html |title=Beta-Lactamase Inhibitors |date=October 2000 |accessdate=2007-08-17 |publisher=Department of Nursing of the Fort Hays State University College of Health and Life Sciences] it still plays an important role by disabling or slowing down the action of beta-lactamase which would normally be a mechanism of bacterial resistance to beta-lactam antibiotics as it lyses them.

Beta-lactamase inhibitors in clinical use include clavulanic acid and its potassium salt (usually combined with amoxicillin or ticarcillin), sulbactam and tazobactam.

References


Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • Beta-lactamase — Beta lactamases are enzymes (EC number|3.5.2.6) produced by some bacteria and are responsible for their resistance to beta lactam antibiotics like penicillins, cephalosporins, cephamycins, ertapenems and carbapenems. These antibiotics have a… …   Wikipedia

  • Beta-lactam — | | | | | | |A beta lactam ring (β lactam) or penam is a lactam with a heteroatomic ring structure, consisting of three carbon atoms and one nitrogen atom [Heterocyclic chemistry T.L. Gilchrist ISBN 0 582 01421 2 ] . Clinical significanceThe beta …   Wikipedia

  • Beta-lactam antibiotic — β lactam antibiotics are a broad class of antibiotics that include penicillin derivatives, cephalosporins, monobactams, carbapenems, and β lactamase inhibitors, that is, any antibiotic agent that contains a β lactam nucleus in its molecular… …   Wikipedia

  • Beta-Lactam-Antibiotika — Strukturformeln (von oben nach unten): β Lactam, Penicilline, Cephalosporine Die β Lactam Antibiotika sind eine Gruppe von Antibiotika/antibakteriellen Antiinfektiva, die alle in ihrer Strukturformel einen viergliedrigen Lactam Ring aufweisen.… …   Deutsch Wikipedia

  • Beta-Lactam-Antibiotikum — Strukturformeln (von oben nach unten): β Lactam, Penicilline, Cephalosporine Die β Lactam Antibiotika sind eine Gruppe von Antibiotika/antibakteriellen Antiinfektiva, die alle in ihrer Strukturformel einen viergliedrigen Lactam Ring aufweisen.… …   Deutsch Wikipedia

  • inhibitor — 1. An agent that restrains or retards physiologic, chemical, or enzymatic action. 2. A nerve, stimulation of which represses activity. SEE ALSO: inhibition. α glucosidase i. an oral agent that aids in th …   Medical dictionary

  • Monoamine oxidase inhibitor — MAOI redirects here. For the Easter Island statues, see Moai. Monoamine oxidase Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. They are particularly effective in treating… …   Wikipedia

  • Acetylcholinesterase inhibitor — Acetylcholine …   Wikipedia

  • Reverse-transcriptase inhibitor — Reverse transcriptase inhibitors (RTIs) are a class of antiretroviral drug used to treat HIV infection, tumors,[1] and cancer.[2] RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase enzyme that retroviruses need to reproduce.… …   Wikipedia

  • Phosphodiesterase inhibitor — A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), therefore preventing the inactivation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”