Gonadoblastoma

Gonadoblastoma

Infobox_Disease
Name = PAGENAME


Caption =
DiseasesDB =
ICD10 =
ICD9 =
ICDO = M9073/1
OMIM =
MedlinePlus =
eMedicineSubj =
eMedicineTopic =
MeshID = D018238
A gonadoblastoma is a complex neoplasm composed of a mixture of gonadal elements, such as large primordial germ cells, immature Sertoli cells or granulosa cells of the sex cord, and gonadal stromal cells.

Associations

Gonadoblastoma is most often associated with abnormal chromosomal karyotype, gonadal dysgenesis, and the presence of a Y chromosome in over 90% of cases.

It has been found in association with Turner's syndrome.cite journal |author=Maggio MC, Liotta A, De Grazia E, Cimador M, Di Pace R, Corsello G |title=Polycystic ovary and gonadoblastoma in Turner's syndrome |journal=Minerva Pediatr. |volume=59 |issue=4 |pages=397–401 |year=2007 |pmid=17947845 |doi=] cite journal |author=Bianco B, Lipay MV, Melaragno MI, Guedes AD, Verreschi IT |title=Detection of hidden Y mosaicism in Turner's syndrome: importance in the prevention of gonadoblastoma |journal=J. Pediatr. Endocrinol. Metab. |volume=19 |issue=9 |pages=1113–7 |year=2006 |pmid=17128558 |doi=]

Classification

Gonadoblastoma is classified as a germ cell tumor.Fact|date=September 2007

Formerly, gonadoblastoma was sometimes regarded as a subset of dysgerminoma. In modern literature, it is sometimes considered to progress to dysgerminoma.cite journal |author=Cooper C, Cooper M, Carter J, Russell P |title=Gonadoblastoma progressing to dysgerminoma in a 55-year-old woman with normal karyotype |journal=Pathology |volume=39 |issue=2 |pages=284–5 |year=2007 |pmid=17454768 |doi=10.1080/00313020701230708]

Treatment

Standard treatment would include surgical exploration via laparotomy. Laparoscopy may be an option if the surgeon is particularly skilled in removing ovarian neoplasms via laparoscopy intact. If the diagnosis of gonadoblastoma is certain, a bilateral salpingo-oopherectomy (BSO) should be performed to remove both the primary tumor and the dysgenic contralateral ovary. If uninvolved, the uterus should be left intact. Modern reproductive endocrinology technology allows patients post BSO to achieve pregnancy via in-vitro fertilization (IVF) with a donor egg.

References

External links

* [http://www.health.am/cr/testis-non-germ-cell-tumors/ www.health.am: Gonadoblastoma]


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • gonadoblastoma — un tumor benigno bastante raro de células germinales, que suelen aparecer en gónadas disgenéticas, a menudo bilateralmente. Suele estar asociado a un cariotipo cromosómico anormal. Puede evolucionar a disgerminona o a otros tumores malignos de… …   Diccionario médico

  • gonadoblastoma — noun A tumour found in an ovary …   Wiktionary

  • gonadoblastoma — Benign neoplasm composed of germ cells, sex cord, stromal cells; appears in cases of mixed or pure gonadal dysgenesis; usually small (1–3 cm) and partially calcified, but may give rise to malignant germ cell tumors, most often… …   Medical dictionary

  • Germ cell tumor — Classification and external resources Micrograph of a seminoma, a common germ cell tumor. ICD 10 C …   Wikipedia

  • Teratoma — Classification and external resources Micrograph of a teratoma showing tissue from all three germ layers: mesoderm (immature cartilage left upper corner of image), endoderm (gastrointestinal glands cente …   Wikipedia

  • Choriocarcinoma — Classification and external resources ICD 10 C58 ICD 9 181 …   Wikipedia

  • TSPY1 — Testis specific protein, Y linked 1, also known as TSPY1, is a human gene. [cite web | title = Entrez Gene: TSPY1 Testis specific protein, Y linked 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7258|… …   Wikipedia

  • Testicular cancer — Classification and external resources 7.4 × 5.5 cm seminoma in a radical orchiectomy specimen. ICD 10 C …   Wikipedia

  • Intersex surgery — is one of several terms referring to surgery performed to correct birth defects or early injuries of the genitalia, primarily for the purposes of making the appearance more normal and to reduce the likelihood of future problems. The recent… …   Wikipedia

  • Germinoma — Classification and external resources Micrograph of a germinoma. H E stain. ICD O: 9060 9061, M …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”