Sulfapyridine

Sulfapyridine

Systematic (IUPAC) name
4-amino-N-pyridin-2-ylbenzenesulfonamide
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a682204
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	000144-83-2 Y
ATC code	J01EB04 QJ01EQ04
PubChem	CID 5336
DrugBank	DB00891
ChemSpider	5145 Y
UNII	Y5V2N1KE8U N
KEGG	D02434 Y
ChEBI	CHEBI:132842 N
ChEMBL	CHEMBL700 Y
Chemical data
Formula	C11H11N3O2S
Mol. mass	249.29 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14) Y Key:GECHUMIMRBOMGK-UHFFFAOYSA-N Y
N(what is this?)  (verify)

Sulfapyridine, original UK spelling Sulphapyridine, is a sulfonamide antibacterial. At one time it was commonly referred to as M&B.

Sulfapyridine is not prescribed for treatment in humans any more. However, it may be used to treat Linear IgA Disease. It is a good antibacterial drug, but its water solubility is very pH dependent. Thus there is a risk of crystallization within the bladder or urethra, which could lead to pain or blockage.

Discovered by May & Baker Ltd and logged in their Test Book on 2 November 1937 under Code No M&B693^[1]. Successfully used to treat Winston Churchill's bacterial pneumonia in 1942. In a subsequent radio broadcast he said "This admirable M&B from which I did not suffer any inconvenience, was used at the earliest moment and, after a week's fever, the intruders were repulsed." In 1944 M&B693 also saved Nero, the Royal Circus lion, from pneumonia.[Glasgow Evening News January 1944.]

The drug sulfasalazine is structurally one molecule of mesalamine linked to one molecule of Sulfapyridine with an azo bond.

References

1. ^ Lesch, John (2007). "Chapter 7". The First Miracle Drugs (illustrated ed.). Oxford University Press. ISBN 019518775X. 

This systemic antibacterial-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Sulfonamide antibiotics Pyridines Antibiotic stubs Wikimedia Foundation. 2010. Игры ⚽ Нужен реферат? Giorgos Nicolaou Jighii River Look at other dictionaries: sulfapyridine — /sul feuh pir i deen , din/, n. Pharm. a sulfanilamide derivative, C11H11N3O2S, formerly used for infections caused by pneumococci, now used primarily for a particular dermatitis. [SULFA(NILAMIDE) + PYRIDINE] * * * …   Universalium sulfapyridine — noun A particular antibacterial sulfonamide …   Wiktionary sulfapyridine — An antibacterial agent of the sulfonamide group. * * * sul·fa·pyr·i·dine or chiefly Brit sul·pha·pyr·i·dine .səl fə pir ə .dēn n a sulfa drug C11H11N3O2S that is derived from pyridine and sulfanilamide and is used in small doses in the treatment… …   Medical dictionary sulfapyridine — n. sulfa drug used to treat certain skin diseases …   English contemporary dictionary sulfapyridine — sul·fa·pyridine …   English syllables sulfapyridine — noun sulfa drug derived from pyridine and sulfanilamide • Hypernyms: ↑sulfa drug, ↑sulfa, ↑sulpha, ↑sulfonamide …   Useful english dictionary Sulfasalazine — Systematic (IUPAC) name 2 hydroxy 5 [(E) 2 {4 [(pyridin 2 yl)sulfamoyl]phenyl}diazen 1 yl]benzoic acid Clinical data Trade names …   Wikipedia Treatment of Crohn's disease — involves first treating the acute symptoms of the disease, then maintaining remission. Treatment initially involves the use of medications to eliminate infections, generally antibiotics, and reduce inflammation, generally aminosalicylate anti… …   Wikipedia Management of Crohn's disease — involves first treating the acute symptoms of the disease, then maintaining remission. Treatment initially involves the use of medications to eliminate infections, generally antibiotics, and reduce inflammation, generally aminosalicylate anti… …   Wikipedia Mesalazine — Systematic (IUPAC) name 5 amino 2 hydroxybenzoic acid Clinical data AHFS/Drugs.com …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”