D-amino acid oxidase activator

D-amino acid oxidase activator
Identifiers
Symbol	DAOA
Alt. symbols	G72, LG72, SG72
Entrez	267012
HUGO	21191
OMIM	607408
RefSeq	NM_172370
UniProt	P59103
Other data
Locus	Chr. 13 q33.2

D-amino acid oxidase activator (DAOA, also known as G72) is a protein enriched in various parts of brain, spinal cord, and testis. DAOA is thought to interact with D-amino acid oxidase, a peroxisomal enzyme, and its gene was associated with schizophrenia in a number of studies.^[1][2] In separate studies it has been shown to confer susceptibility to bipolar disorder. Therefore it has been important in researching whether the Kraepelinian dichotomy is genuine. The gene itself was discovered during an investigation of chromosomal 13q22-q34 region,^[3] which was previously linked to schizophrenia. G72 is transcribed into several proteins due to alternative splicing; the longest protein is called LG72 and consists of 153 amino acids. Although the protein was initially found to interact with DAO in yeast 2-hybrid experiment, one recent in vivo experiment showed LG72 presence only in mitochondria and failed to confirm the interaction.^[4] The epxression of DAOA may be regulated by the long non-coding RNA DAOA-AS1.^[3]

References

1. ^ Detera-Wadleigh SD, McMahon FJ (2006). "G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis". Biol. Psychiatry 60 (2): 106–14. doi:10.1016/j.biopsych.2006.01.019. PMID 16581030. 
2. ^ Gene Overview of All Published Schizophrenia-Association Studies for DAOA, schizophreniaforum.org
3. ^ ^{a b} Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, Bougueleret L, Barry C, Tanaka H, La Rosa P, Puech A, Tahri N, Cohen-Akenine A, Delabrosse S, Lissarrague S, Picard FP, Maurice K, Essioux L, Millasseau P, Grel P, Debailleul V, Simon AM, Caterina D, Dufaure I, Malekzadeh K, Belova M, Luan JJ, Bouillot M, Sambucy JL, Primas G, Saumier M, Boubkiri N, Martin-Saumier S, Nasroune M, Peixoto H, Delaye A, Pinchot V, Bastucci M, Guillou S, Chevillon M, Sainz-Fuertes R, Meguenni S, Aurich-Costa J, Cherif D, Gimalac A, Van Duijn C, Gauvreau D, Ouellette G, Fortier I, Raelson J, Sherbatich T, Riazanskaia N, Rogaev E, Raeymaekers P, Aerssens J, Konings F, Luyten W, Macciardi F, Sham PC, Straub RE, Weinberger DR, Cohen N, Cohen D, Ouelette G, Realson J (2002). "Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13675–80. doi:10.1073/pnas.182412499. PMC 129739. PMID 12364586. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=129739. 
4. ^ Kvajo M, Dhilla A, Swor DE, Karayiorgou M, Gogos JA (2007). "Evidence implicating the candidate schizophrenia/bipolar disorder susceptibility gene G72 in mitochondrial function". Molecular Psychiatry 13 (7): 685–696. doi:10.1038/sj.mp.4002052. PMID 17684499. 

External links

• From schizophrenia research forum website:
  • G72 Protein Shows Up in Mitochondria
  • Genetic Studies of DAOA(G72)/G30 Bridge Kraepelinian Divide