- Asymmetric synthesis
Asymmetric synthesis, also called chiral synthesis, enantioselective synthesis or stereoselective synthesis, is
organic synthesiswhich introduces one or more new and desired elements of chirality. [GoldBookRef|title=asymmetric synthesis| file = A00484] [GoldBookRef|title=stereoselective synthesis|file = S05990] This is important in the field of pharmaceuticals because the different enantiomers or diastereomers of a molecule often have different biological activity.
There are three main approaches to asymmetric synthesis:
chiral pool synthesis
* chiral auxiliaries
* asymmetric catalysis
In practice, a mixture of all three is often used in order to maximize the advantages of each method.
Chirality must be introduced to the substance first. Then, it must be maintained. Care needs to be taken when planning the synthesis: the chirality might be removed by a chemical change that makes the substance
isotropic. This process is called epimerization. For example, a SN1 substitution reaction converts a molecule that is chiral by merit of non-planarity into a planar molecule, which has no handedness. (To visualise, draw the outlines of both of your hands on paper, and cut the images out. You can now superimpose the images, even if the hands themselves do not superimpose.) In a SN2 substitution reaction on the other hand the chirality inverts, i.e. when you start with a right-handed mixture, you'll end up with left-handed one. (A visualization could be inverting an umbrella. The mechanism looks just the same.)
Chiral pool synthesis
Chiral pool synthesisis the easiest approach: a chiral starting material is manipulated through successive reactions using achiral reagents which retain its chirality to obtain the desired target molecule. This is especially attractive for target molecules having the similar chirality to a relatively inexpensive naturally occurring building block such as a sugaror amino acid. However, the number of possible reactions the molecule can undergo are restricted, and tortuous synthetic routes may be required. Also, this approach requires a stoichiometric amount of the enantiopurestarting material, which may be rather expensive if not occurring in nature, whereas chiral catalysis requires only a catalytic amount of chiral material.
What many strategies in chiral synthesis have in common is
asymmetric induction. The aim is to make enantiomers into diastereomers, since diastereomers have different reactivity, but enantiomers do not. To make enantiomers into diastereomers, the reagents or the catalyst need to be incorporated with an enantiopure chiral center. The reaction will now proceed differently for different enantiomers, because the transition state of the reaction can exist in two diastereomers with respect to the enantiopure center, and these diastereomers react differently.
Asymmetric induction can also occur intramolecularly when given a chiral starting material. This chirality transfer can be exploited, especially when the goal is to make several consecutive chiral centers to give a specific enantiomer of a specific diastereomer. An
aldol reaction, for example, is inherently diastereoselective; if the aldehyde is enantiopure, the resulting aldol adduct is diastereomerically and enantiomerically pure.
One asymmetric induction strategy is the use of a
chiral auxiliarywhich forms an adduct to the starting materials and physically blocks the other trajectory for attack, leaving only the desired trajectory open. Assuming the chiral auxiliary is enantiopure, the different trajectories are not equivalent, but diastereomeric. The auxiliary shares problems similar to protecting groups; like protecting groups, auxiliaries require a reaction step to add and another to remove, increasing cost and decreasing yield.
The oldest asymmetric synthesis is the enantioselective
decarboxylationof the malonic acid"2-ethyl-2-methylmalonic acid" mediated by brucine(forming the salt) as reported by Willy Marckwaldin 1904: [cite journal | doi = 10.1002/cber.19040370165 | title = Ueber asymmetrische Synthese | year = 1904 | author = Marckwald, W. | journal = Berichte der deutschen chemischen Gesellschaft | volume = 37 | pages = 349] [cite journal | doi = 10.1002/cber.19040370226 | title = Ueber asymmetrische Synthese | year = 1904 | author = Marckwald, W. | journal = Berichte der deutschen chemischen Gesellschaft | volume = 37 | pages = 1368]
Small amounts of chiral, enantiomerically pure (or enriched) catalysts promote reactions and lead to the formation of large amounts of enantiomerically pure or enriched products. [a) Comprehensive Asymmetric Catalysis (Jacobsen, Pfaltz, Yamamoto), Springer, 1999; b) Catalytic Asymmetric Synthesis, (Ojima), Wiley, 2000.] [cite journal | author = M. Heitbaum, F. Glorius and I. Escher | title = Asymmetric Heterogeneous Catalysis | year = 2006 | journal =
Angewandte Chemie International Edition| volume = 45 | issue = 29 | pages = 4732–4762 | doi = 10.1002/anie.200504212] [Asymmetric Catalysis on Industrial Scale, (Blaser, Schmidt), Wiley-VCH, 2004.] Mostly, three different kinds of chiral catalysts are employed:
# metal ligand complexes derived from
biocatalysts.The first methods were pioneered by William S. Knowlesand Ryoji Noyori( Nobel Prize in Chemistry2001). Knowles in 1968 [Nobel prize 2001 www.nobelprize.org [http://nobelprize.org/nobel_prizes/chemistry/laureates/2001/public.html Link] ] replaced the achiral triphenylphosphineligands in Wilkinson's catalystby the chiral phosphine ligands P(Ph)(Me)(Propyl) thus creating the first asymmetric catalyst. This experimental catalyst was employed in an asymmetric hydrogenationwith a modest 15% enantiomeric excessresult. The methodology was ultimately used by him (while working for the Monsantocompany) in an asymmetric hydrogenation step in the industrial production of L-DOPA:
In the same year and independently Noyori [cite journal | title = Homogeneous catalysis in the decomposition of diazo compounds by copper chelates: Asymmetric carbenoid reactions | journal = Tetrahedron | volume = 24 | issue = 9 | year = 1968 | pages = 3655–3669 | author = H. Nozaki, H. Takaya, S. Moriuti, R. Noyori | doi = 10.1016/S0040-4020(01)91998-2] published his chiral ligand for a
cyclopropanationreaction of styrene. In common with Knowles the enantiomeric excess for this first generation ligand was disappointingly low: 6%.
Examples of asymmetric catalysis include:
BINAP, a chiral phosphine, used in combination with compounds of rutheniumor rhodium. These complexes catalyse the hydrogenationof functionalised alkenes well on only one face of the molecule. This process also developed by Ryoji Noyoriis commercialized as the industrial synthesis of mentholusing a chiral BINAP- rhodiumcomplex.
* The other part of that Nobel prize concerned the
Naproxenis synthesized with a chiral phosphine ligand in a Hydrocyanationreaction
asymmetric catalytic reductionand oxidation
Biocatalysis & organocatalysis
Biocatalysismakes use of enzymes to effect chemical reagents stereoselectively. Some small organic molecules can also be used to help accelerate the desired reaction; this method is known as organocatalysis. If the organic molecule is chiral, it may react preferentially with the substrate of a certain chirality.
Apart from asymmetric synthesis, racemic mixtures of compounds may be separated by various techniques in
chiral resolution. Where the cost in time and money of making such racemic mixtures is low, or if both enantiomers may find use, this approach may remain cost-effective.
Aza-Baylis-Hillman reaction, for the use of a chiral ionic liquid in asymmetric synthesis.
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