EGF module-containing mucin-like hormone receptor

protein
Name = egf-like module containing, mucin-like, hormone receptor-like 1
caption =


width =
HGNCid = 3336
Symbol = EMR1
AltSymbols = TM7LN3
EntrezGene = 2015
OMIM = 600493
RefSeq = NM_001974
UniProt = Q14246
PDB =
ECnumber =
Chromosome = 19
Arm = p
Band = 13.3
LocusSupplementaryData = protein
Name = egf-like module containing, mucin-like, hormone receptor-like 2
caption =


width =
HGNCid = 3337
Symbol = EMR2
AltSymbols =
EntrezGene = 30817
OMIM = 606100
RefSeq = NM_152916
UniProt = Q9UHX3
PDB =
ECnumber =
Chromosome = 19
Arm = p
Band = 13.1
LocusSupplementaryData = protein
Name = egf-like module containing, mucin-like, hormone receptor-like 3
caption =


width =
HGNCid = 23647
Symbol = EMR3
AltSymbols =
EntrezGene = 84658
OMIM = 606101
RefSeq = NM_032571
UniProt = Q9BY15
PDB =
ECnumber =
Chromosome = 19
Arm = p
Band = 13.1
LocusSupplementaryData = protein
Name = egf-like module containing, mucin-like, hormone receptor-like 4
caption =


width =
HGNCid = 19240
Symbol = EMR4
AltSymbols = GPR127
EntrezGene = 347749
OMIM =
RefSeq = XM_940358
UniProt = Q86SQ3
PDB =
ECnumber =
Chromosome = 19
Arm = p
Band = 13.3
LocusSupplementaryData =

The EGF module-containing Mucin-like hormone Receptors (EMRs) are closely related subgroup of G protein-coupled receptors (GPCRs). These receptors are comprised of a unique hybrid structure in which an extracellular epidermal growth factor (EGF)-like domain is fused to a GPCR domain through a mucin-like stalk.cite journal | author = Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M | title = EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments | journal = Genomics | volume = 26 | issue = 2 | pages = 334–44 | year = 1995 | pmid = 7601460 | doi = | issn = ] cite journal | author = Lin HH, Stacey M, Hamann J, Gordon S, McKnight AJ | title = Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97 | journal = Genomics | volume = 67 | issue = 2 | pages = 188–200 | year = 2000 | pmid = 10903844 | doi = 10.1006/geno.2000.6238 | issn = ] cite journal | author = Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ | title = Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils | journal = J. Biol. Chem. | volume = 276 | issue = 22 | pages = 18863–70 | year = 2001 | pmid = 11279179 | doi = 10.1074/jbc.M101147200 | issn = ] cite journal | author = Caminschi I, Vandenabeele S, Sofi M, McKnight AJ, Ward N, Brodnicki TC, Toy T, Lahoud M, Maraskovsky E, Shortman K, Wright MD | title = Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE | journal = DNA Seq. | volume = 17 | issue = 1 | pages = 8–14 | year = 2006 | pmid = 16753812 | doi = 10.1080/10425170500355737 | issn = ] There are four variants of EMR labeled 1-4, each encoded by a separate gene. These receptors are predominately expressed in cells of the immune system and bind ligands such as CD55.cite journal | author = Kwakkenbos MJ, Kop EN, Stacey M, Matmati M, Gordon S, Lin HH, Hamann J | title = The EGF-TM7 family: a postgenomic view | journal = Immunogenetics | volume = 55 | issue = 10 | pages = 655–66 | year = 2004 | pmid = 14647991 | doi = 10.1007/s00251-003-0625-2 | issn = ]

References

External links

* [http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3083 IUPHAR GPCR Database - EMR1 receptor]
* [http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3084 IUPHAR GPCR Database - EMR2 receptor]
* [http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3085 IUPHAR GPCR Database - EMR3 receptor]
* [http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3086 IUPHAR GPCR Database - EMR4 receptor]
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