GPR30

GPR30 (G Protein-coupled Receptor 30) is an integral membrane protein with high affinity for estrogen.cite journal | author = Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER | title = A transmembrane intracellular estrogen receptor mediates rapid cell signaling | journal = Science | volume = 307 | issue = 5715 | pages = 1625–30 | year = 2005 | pmid = 15705806 | doi = 10.1126/science.1106943 | issn = ] cite journal | author = Filardo EJ, Thomas P | title = GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release | journal = Trends Endocrinol. Metab. | volume = 16 | issue = 8 | pages = 362–7 | year = 2005 | pmid = 16125968 | doi = 10.1016/j.tem.2005.08.005 | issn = ] cite journal | author = Manavathi B, Kumar R | title = Steering estrogen signals from the plasma membrane to the nucleus: two sides of the coin | journal = J. Cell. Physiol. | volume = 207 | issue = 3 | pages = 594–604 | year = 2006 | pmid = 16270355 | doi = 10.1002/jcp.20551 | issn = ] cite journal | author = Prossnitz ER, Arterburn JB, Sklar LA | title = GPR30: A G protein-coupled receptor for estrogen | journal = Mol. Cell. Endocrinol. | volume = 265-266 | issue = | pages = 138–42 | year = 2007 | pmid = 17222505 | doi = 10.1016/j.mce.2006.12.010 | issn = ]

GPR30 is also referred to as G Protein-coupled Estrogen Receptor 1 (GPER).

PBB_Summary
section_title =
summary_text = This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized.cite web | title = Entrez Gene: GPR30 G protein-coupled receptor 30| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2852| accessdate = ]

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1360 IUPHAR GPCR Database - Estrogen (G protein coupled) receptor]
*

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Filardo EJ |title=Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer. |journal=J. Steroid Biochem. Mol. Biol. |volume=80 |issue= 2 |pages= 231–8 |year= 2002 |pmid= 11897506 |doi=
*cite journal | author=Filardo EJ, Thomas P |title=GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release. |journal=Trends Endocrinol. Metab. |volume=16 |issue= 8 |pages= 362–7 |year= 2005 |pmid= 16125968 |doi= 10.1016/j.tem.2005.08.005
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Owman C, Blay P, Nilsson C, Lolait SJ |title=Cloning of human cDNA encoding a novel heptahelix receptor expressed in Burkitt's lymphoma and widely distributed in brain and peripheral tissues. |journal=Biochem. Biophys. Res. Commun. |volume=228 |issue= 2 |pages= 285–92 |year= 1996 |pmid= 8920907 |doi= 10.1006/bbrc.1996.1654
*cite journal | author=Feng Y, Gregor P |title=Cloning of a novel member of the G protein-coupled receptor family related to peptide receptors. |journal=Biochem. Biophys. Res. Commun. |volume=231 |issue= 3 |pages= 651–4 |year= 1997 |pmid= 9070864 |doi= 10.1006/bbrc.1997.6161
*cite journal | author=Kvingedal AM, Smeland EB |title=A novel putative G-protein-coupled receptor expressed in lung, heart and lymphoid tissue. |journal=FEBS Lett. |volume=407 |issue= 1 |pages= 59–62 |year= 1997 |pmid= 9141481 |doi=
*cite journal | author=Carmeci C, Thompson DA, Ring HZ, "et al." |title=Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer. |journal=Genomics |volume=45 |issue= 3 |pages= 607–17 |year= 1998 |pmid= 9367686 |doi= 10.1006/geno.1997.4972
*cite journal | author=Takada Y, Kato C, Kondo S, "et al." |title=Cloning of cDNAs encoding G protein-coupled receptor expressed in human endothelial cells exposed to fluid shear stress. |journal=Biochem. Biophys. Res. Commun. |volume=240 |issue= 3 |pages= 737–41 |year= 1998 |pmid= 9398636 |doi= 10.1006/bbrc.1997.7734
*cite journal | author=O'Dowd BF, Nguyen T, Marchese A, "et al." |title=Discovery of three novel G-protein-coupled receptor genes. |journal=Genomics |volume=47 |issue= 2 |pages= 310–3 |year= 1998 |pmid= 9479505 |doi= 10.1006/geno.1998.5095
*cite journal | author=Filardo EJ, Quinn JA, Bland KI, Frackelton AR |title=Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. |journal=Mol. Endocrinol. |volume=14 |issue= 10 |pages= 1649–60 |year= 2001 |pmid= 11043579 |doi=
*cite journal | author=Filardo EJ, Quinn JA, Frackelton AR, Bland KI |title=Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis. |journal=Mol. Endocrinol. |volume=16 |issue= 1 |pages= 70–84 |year= 2002 |pmid= 11773440 |doi=
*cite journal | author=Ahola TM, Purmonen S, Pennanen P, "et al." |title=Progestin upregulates G-protein-coupled receptor 30 in breast cancer cells. |journal=Eur. J. Biochem. |volume=269 |issue= 10 |pages= 2485–90 |year= 2002 |pmid= 12027886 |doi=
*cite journal | author=Ahola TM, Manninen T, Alkio N, Ylikomi T |title=G protein-coupled receptor 30 is critical for a progestin-induced growth inhibition in MCF-7 breast cancer cells. |journal=Endocrinology |volume=143 |issue= 9 |pages= 3376–84 |year= 2002 |pmid= 12193550 |doi=
*cite journal | author=Ahola TM, Alkio N, Manninen T, Ylikomi T |title=Progestin and G protein-coupled receptor 30 inhibit mitogen-activated protein kinase activity in MCF-7 breast cancer cells. |journal=Endocrinology |volume=143 |issue= 12 |pages= 4620–6 |year= 2002 |pmid= 12446589 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Hamza A, Sarma MH, Sarma RH |title=Plausible interaction of an alpha-fetoprotein cyclopeptide with the G-protein-coupled receptor model GPR30: docking study by molecular dynamics simulated annealing. |journal=J. Biomol. Struct. Dyn. |volume=20 |issue= 6 |pages= 751–8 |year= 2004 |pmid= 12744705 |doi=
*cite journal | author=Kanda N, Watanabe S |title=17Beta-estradiol enhances the production of nerve growth factor in THP-1-derived macrophages or peripheral blood monocyte-derived macrophages. |journal=J. Invest. Dermatol. |volume=121 |issue= 4 |pages= 771–80 |year= 2003 |pmid= 14632195 |doi= 10.1046/j.1523-1747.2003.12487.x
*cite journal | author=Kanda N, Watanabe S |title=17beta-estradiol inhibits oxidative stress-induced apoptosis in keratinocytes by promoting Bcl-2 expression. |journal=J. Invest. Dermatol. |volume=121 |issue= 6 |pages= 1500–9 |year= 2004 |pmid= 14675202 |doi= 10.1111/j.1523-1747.2003.12617.x

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