Feverfew

Feverfew
This article is about the Eurasian Asteraceae species. For the North American Asteraceae genus, see Parthenium. For the band, see The Feverfew.
Feverfew
Scientific classification
Kingdom: Plantae
(unranked): Angiosperms
(unranked): Eudicots
(unranked): Asterids
Order: Asterales
Family: Asteraceae
Genus: Tanacetum
Species: T. parthenium
Binomial name
Tanacetum parthenium
(L.) Sch. Bip.

Feverfew (Tanacetum parthenium; syn. Chrysanthemum parthenium (L.) Pers., Pyrethrum parthenium Sm.) is a traditional medicinal herb which is found in many old gardens, and is also occasionally grown for ornament. The plant grows into a small bush up to around 46 cm (18 in) high, with citrus-scented leaves and is covered by flowers reminiscent of daisies. It spreads rapidly, and they will cover a wide area after a few years. It is also commonly seen in the literature by its synonyms, Chrysanthemum parthenium (L.) Bernh. and Pyrethrum parthenium (L.) Sm.

Feverfew was native to Eurasia; specifically the Balkan Peninsula, Anatolia and the Caucasus, but cultivation has spread it around the world and it is now also found in Europe, the Mediterranean, North America and Chile.[1]

Contents

Uses

The word "feverfew" derives from the Latin febrifugia, meaning "fever reducer."[2] The plant has been used as an herbal treatment to reduce fever and to treat headaches, arthritis and digestive problems, although there is no scientific evidence supporting anything beyond a placebo effect.[3][4][5]

The active ingredients in feverfew include parthenolide and tanetin. There has been some scientific interest in parthenolide, which has been shown to induce apoptosis in some cancer cell lines in vitro and potentially to target cancer stem cells.[6][7][8] There are no published studies of parthenolide or feverfew in humans with cancer.

Long-term use of feverfew followed by abrupt discontinuation may induce a withdrawal syndrome featuring rebound headaches and muscle and joint pains.[2] Feverfew can cause allergic reactions, including contact dermatitis.[9] Other side effects have included gastrointestinal upset such as nausea, vomiting, abdominal pain, diarrhea, and flatulence. When the herb is chewed or taken orally it can cause mouth ulcers and swelling and numbness of the mouth.[2]

Feverfew should not be taken by pregnant women.[10] It may interact with blood thinners and increase the risk of bleeding, and may also interact with a variety of medications metabolized by the liver.[2]

Cultivation

A perennial herb, which should be planted in full sun, 38–46 cm (15–18 in) apart and grows up to 61 cm (24 in) tall. It is hardy to USDA zone 5 (−30 °C (−22 °F)) and should be cut back to the ground in the fall. Outside of its native range it can become an invasive weed.

References

  1. ^ Jeffrey C (2001). "Tanacetum parthenium". Mansfeld's World Database of Agricultural and Horticultural Crops. http://mansfeld.ipk-gatersleben.de/pls/htmldb_pgrc/f?p=185:46:3959160511697399::NO::module,mf_use,source,taxid,akzname:mf,,volksnam,32354,Tanacetum%20parthenium. 
  2. ^ a b c d "Feverfew". University of Maryland. http://www.umm.edu/altmed/articles/feverfew-000243.htm. Retrieved October 6, 2011. 
  3. ^ Pittler, MH; Ernst, E (2004). Pittler, Max H. ed. "Feverfew for preventing migraine". Cochrane Database of Systematic Reviews (1): CD002286. doi:10.1002/14651858.CD002286.pub2. PMID 14973986. 
  4. ^ "Feverfew". National Center for Complementary and Alternative Medicine. July 2010. http://nccam.nih.gov/health/feverfew/. Retrieved October 6, 2011. 
  5. ^ Pareek A, Suthar M, Rathore GS, Bansal V (January 2011). "Feverfew (Tanacetum parthenium L.): A systematic review". Pharmacogn Rev 5 (9): 103–10. doi:10.4103/0973-7847.79105. PMID 22096324. 
  6. ^ Guzman ML, Rossi RM, Karnischky L, et al. (June 2005). "The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells". Blood 105 (11): 4163–9. doi:10.1182/blood-2004-10-4135. PMC 1895029. PMID 15687234. http://bloodjournal.hematologylibrary.org/content/105/11/4163.long. 
  7. ^ Guzman ML, Jordan CT (September 2005). "Feverfew: weeding out the root of leukaemia". Expert Opin Biol Ther 5 (9): 1147–52. doi:10.1517/14712598.5.9.1147. PMID 16120045. 
  8. ^ Lesiak K, Koprowska K, Zalesna I, Nejc D, Düchler M, Czyz M (February 2010). "Parthenolide, a sesquiterpene lactone from the medical herb feverfew, shows anticancer activity against human melanoma cells in vitro". Melanoma Res. 20 (1): 21–34. doi:10.1097/CMR.0b013e328333bbe4. PMID 19949351. 
  9. ^ Killoran, CE; Crawford, GH; Pedvis-Leftick, A (2007). "Two cases of compositae dermatitis exacerbated by moisturizer containing feverfew". Dermatitis : contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group 18 (4): 225–9. PMID 18021604.  edit
  10. ^ Yao M, Ritchie HE, Brown-Woodman PD (November 2006). "A reproductive screening test of feverfew: is a full reproductive study warranted?". Reprod. Toxicol. 22 (4): 688–93. doi:10.1016/j.reprotox.2006.04.014. PMID 16781113. http://linkinghub.elsevier.com/retrieve/pii/S0890-6238(06)00102-X. 

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Look at other dictionaries:

  • Feverfew — Fe ver*few (f[=e] v[ e]r*f[=u]), n. [AS. feferfuge, fr. L. febrifugia. See {fever}, {Fugitive}, and cf. {Febrifuge}.] (Bot.) A perennial plant ({Pyrethrum Parthenium}, or {Chrysanthemum Parthenium}) allied to camomile, having finely divided… …   The Collaborative International Dictionary of English

  • feverfew — O.E. feferfuge, from L.L. febrifugia, from L. febris fever (see FEVER (Cf. fever)) + fugare put to flight; so called for its medical usage. The modern English word probably is from an Anglo French source …   Etymology dictionary

  • feverfew — ► NOUN ▪ an aromatic plant with feathery leaves and daisy like flowers, used as a herbal remedy for headaches. ORIGIN Latin febrifuga, from febris fever + fugare drive away …   English terms dictionary

  • feverfew — [fē′vər fyo͞o΄] n. [ME fevyrfue < OE feverfuge & Anglo Fr * fewerfue, both < LL febrifugia < L febris, FEVER + fugia < fugare, to drive away; akin to fugere, to flee: see FUGITIVE] a bushy plant (Chrysanthemum parthenium) of the… …   English World dictionary

  • feverfew — vaistinis skaistenis statusas T sritis vardynas apibrėžtis Astrinių šeimos dekoratyvinis, vaistinis augalas (Tanacetum parthenium), paplitęs pietų Europoje. atitikmenys: lot. Tanacetum parthenium angl. feverfew isp. altamisa šaltinis Valstybinės… …   Lithuanian dictionary (lietuvių žodynas)

  • feverfew — noun Etymology: Middle English, from Old English feferfuge, from Late Latin febrifugia centaury more at febrifuge Date: 15th century a perennial European composite herb (Chrysanthemum parthenium) widely cultivated as an ornamental …   New Collegiate Dictionary

  • feverfew — /fee veuhr fyooh /, n. a bushy composite plant, Chrysanthemum parthenium, bearing small white flowers, formerly used as a remedy for fever and headache. [1400 50; late ME < AF *feverfue (r. early ME fever fugie, OE feferfuge) < LL febrifugia. See …   Universalium

  • feverfew — noun A European aromatic perennial herb, Tanacetum parthenium (or Chrysanthemum parthenium or Pyrethrum parthenium), having daisy like flowers; valued as a traditional medicine especially for headaches …   Wiktionary

  • feverfew — fe·ver·few (feґvər fu″) [A.S. feferfuge, febrifuge, from L. febrifugia][NF] the dried leaves of Tanacetum parthenium, used for migraine, arthritis, rheumatic diseases, and allergy; it has a wide variety of uses in folk medicine …   Medical dictionary

  • feverfew — n. type of perennial flowering plant that can be used medicinally to reduce fever …   English contemporary dictionary

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