TRPV4

Transient receptor potential cation channel, subfamily V, member 4, also known as TRPV4, is a human gene.cite journal | author = Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant TD | title = OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity | journal = Nat. Cell Biol. | volume = 2 | issue = 10 | pages = 695–702 | year = 2000 | month = October | pmid = 11025659 | doi = 10.1038/35036318 | url = | issn = ] cite journal | author = Liedtke W, Choe Y, Martí-Renom MA, Bell AM, Denis CS, Sali A, Hudspeth AJ, Friedman JM, Heller S | title = Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor | journal = Cell | volume = 103 | issue = 3 | pages = 525–35 | year = 2000 | month = October | pmid = 11081638 | pmc = 2211528 | doi = 10.1016/S0092-8674(00)00143-4 | url = | issn = ]

This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels.cite journal | author = Harteneck C, Plant TD, Schultz G | title = From worm to man: three subfamilies of TRP channels | journal = Trends Neurosci. | volume = 23 | issue = 4 | pages = 159–66 | year = 2000 | month = April | pmid = 10717675 | doi = 10.1016/S0166-2236(99)01532-5 | url = | issn = ] cite journal | author = Clapham DE, Julius D, Montell C, Schultz G | title = International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels | journal = Pharmacol. Rev. | volume = 57 | issue = 4 | pages = 427–50 | year = 2005 | month = December | pmid = 16382100 | doi = 10.1124/pr.57.4.6 | url = | issn = ] cite journal | author = Plant TD, Strotmann R | title = TRPV4 | journal = Handb Exp Pharmacol | volume = | issue = 179 | pages = 189–205 | year = 2007 | pmid = 17217058 | doi = 10.1007/978-3-540-34891-7_11 | url = | issn = ] The encoded protein is a Ca²⁺-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure.cite journal | author = Harteneck C, Reiter B | title = TRP channels activated by extracellular hypo-osmoticity in epithelia | journal = Biochem. Soc. Trans. | volume = 35 | issue = Pt 1 | pages = 91–5 | year = 2007 | month = February | pmid = 17233610 | doi = 10.1042/BST0350091 | url = | issn = ] Two transcript variants encoding different isoforms have been found for this gene. [cite web | title = Entrez Gene: TRPV4 transient receptor potential cation channel, subfamily V, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59341| accessdate = ]

ee also

* TRPV

References

External links

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