RAC1

Rac1 (Ras-related C3 botulinum toxin substrate 1) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.cite journal |author=Ridley A. |year=2006 |title=Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking |journal=Trends Cell Biol |volume=16 |issue=10 |pages=522–9 |issn=0962-8924 |doi=10.1016/j.tcb.2006.08.006] It is encoded by the gene RAC1. It is a pleiotropic regulator of many cellular processes, including the cell cycle, cell-cell adhesion, motility (through the actin network), and of epithelial differentiation (proposed to be necessary for maintaining epidermal stem cells).

Gene

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [cite web | title = Entrez Gene: RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5879| accessdate = ]

References

Further reading

*PBB_Further_reading
citations =
*cite journal | author=Dorseuil O, Gacon G |title= [Signal transduction by Rac small G proteins in phagocytes] |journal=C. R. Seances Soc. Biol. Fil. |volume=191 |issue= 2 |pages= 237–46 |year= 1997 |pmid= 9255350 |doi=
*cite journal | author=Ramakers GJ |title=Rho proteins, mental retardation and the cellular basis of cognition. |journal=Trends Neurosci. |volume=25 |issue= 4 |pages= 191–9 |year= 2002 |pmid= 11998687 |doi=

External links

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