Mosapride

Mosapride
Mosapride
Systematic (IUPAC) name
(RS)-4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)morpholin-2-yl]methyl}benzamide
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 112885-41-3 YesY
ATC code None
PubChem CID 119584
IUPHAR ligand 242
ChemSpider 106780 YesY
UNII I8MFJ1C0BY N
KEGG D08236 YesY
ChEMBL CHEMBL60889 YesY
Chemical data
Formula C21H25ClFN3O3 
Mol. mass 421.893 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist[1] which accelerates gastric emptying and is used for the treatment of acid reflux[2], irritable bowel syndrome and functional dyspepsia.[3]


References

  1. ^ Kato S, Morie T, Yoshida N. Synthesis and biological activities of metabolites of mosapride, a new gastroprokinetic agent. Chemical and Pharmaceutical Bulletin (Tokyo). 1995 Apr;43(4):699-702.
  2. ^ Ruth M, Hamelin B, Rohss K, Lundell L. The effect of mosapride, a novel prokinetic, on acid reflux variables in patients with gastro-oesophageal reflux disease. Alimentary Pharmacology and Therapeutics. 1998 Jan;12(1):35-40.
  3. ^ Mizuta Y, Shikuwa S, Isomoto H, Mishima R, Akazawa Y, Masuda J, Omagari K, Takeshima F, Kohno S. Recent insights into digestive motility in functional dyspepsia. Journal of Gastroenterology. 2006 Nov;41(11):1025-40.