Indoprofen

Drugbox
IUPAC_name = 2- [4-(1-oxo-1,3-dihydro-2"H"-isoindol-2-yl)
phenyl] propanoic acid

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CAS_number = 31842-01-0
ATC_prefix = M01
ATC_suffix = AE10
PubChem = 3718
DrugBank =
C=17|H=15|N=1|O=3
molecular_weight = 281.306 g/mol
bioavailability = High (rapid and complete absorption)
protein_bound =
metabolism = Glucuronidation
elimination_half-life = 2.3 hours
excretion = Renal
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status = Withdrawn
routes_of_administration = Oral

Indoprofen is a non-steroidal anti-inflammatory drug. It was withdrawn worldwide in the 1980s after postmarketing reports of severe gastrointestinal bleeding.cite web | url = http://www.ninds.nih.gov/news_and_events/news_articles/news_article_SMA_indoprofen.htm | last = Frazin | first = Natalie | title = Pain Reliever May Provide Clues for Treating Spinal Muscular Atrophy | date = March 9 2005 | accessdate = 2007-10-06 | publisher = United States National Institute of Neurological Disorders and Stroke]

A 2004 study using high-throughput screening found indoprofen to increase production of the survival of motor neuron protein, suggesting it may provide insight into treatments for spinal muscular atrophies. [cite journal |author=Lunn MR, Root DE, Martino AM, "et al" |title=Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism |journal=Chem Biol |volume=11 |issue=11 |pages=1489–93 |year=2004 |pmid=15555999 |doi=10.1016/j.chembiol.2004.08.024]

References