- PRKACA
Protein kinase, cAMP-dependent, catalytic, alpha, also known as PRKACA, is a human
gene .PBB_Summary
section_title =
summary_text = cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating thecAMP-dependent protein kinase (AMPK), which transduces the signal throughphosphorylation of different target proteins. The inactiveholoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [cite web | title = Entrez Gene: PRKACA protein kinase, cAMP-dependent, catalytic, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5566| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Morishima-Kawashima M, Hasegawa M, Takio K, "et al." |title=Hyperphosphorylation of tau in PHF. |journal=Neurobiol. Aging |volume=16 |issue= 3 |pages= 365–71; discussion 371–80 |year= 1995 |pmid= 7566346 |doi=
*cite journal | author=Deng X, Kornblau SM, Ruvolo PP, May WS |title=Regulation of Bcl2 phosphorylation and potential significance for leukemic cell chemoresistance. |journal=J. Natl. Cancer Inst. Monographs |volume= |issue= 28 |pages= 30–7 |year= 2003 |pmid= 11158204 |doi=
*cite journal | author=Ali A, Hoeflich KP, Woodgett JR |title=Glycogen synthase kinase-3: properties, functions, and regulation. |journal=Chem. Rev. |volume=101 |issue= 8 |pages= 2527–40 |year= 2002 |pmid= 11749387 |doi=
*cite journal | author=Holm C |title=Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. |journal=Biochem. Soc. Trans. |volume=31 |issue= Pt 6 |pages= 1120–4 |year= 2004 |pmid= 14641008 |doi= 10.1042/PBB_Controls
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