3-hydroxyisobutyrate dehydrogenase
- 3-hydroxyisobutyrate dehydrogenase
In enzymology, a 3-hydroxyisobutyrate dehydrogenase (EC number|1.1.1.31) is an enzyme that catalyzes the chemical reaction
:3-hydroxy-2-methylpropanoate + NAD+ 2-methyl-3-oxopropanoate + NADH + H+
Thus, the two substrates of this enzyme are 3-hydroxy-2-methylpropanoate and NAD+, whereas its 3 products are 2-methyl-3-oxopropanoate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-hydroxy-2-methylpropanoate:NAD+ oxidoreductase. This enzyme is also called beta-hydroxyisobutyrate dehydrogenase. This enzyme participates in valine, leucine and isoleucine degradation.
tructural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1WP4, PDB link|2CVZ, PDB link|2GF2, PDB link|2H78, and PDB link|2I9P.
References
*
External links
::"The CAS registry number for this enzyme class is CAS registry|9028-39-1."
Gene Ontology (GO) codes
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