Vesamicol

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ImageFile=Vesamicol.pngImageSize=200px
IUPACName=2-(4-Phenyl-1-piperidinyl)-1-cyclohexanol
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CASNo=22232-64-0
PubChem=5662
SMILES=C1CCC(C(C1)N2CCC(CC2)C3=CC=CC=C3)O
Section2=Chembox Properties
Formula=C₁₇H₂₅NO
MolarMass=259.39 g/mol
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Vesamicol is an experimental drug, acting presynaptically on acetylcholine (ACh) synthesis.cite journal |author=Salin-Pascual RJ, Jimenez-Anguiano A |title=Vesamicol, an acetylcholine uptake blocker in presynaptic vesicles, suppresses rapid eye movement (REM) sleep in the rat |journal=Psychopharmacology |volume=121 |issue=4 |pages=485–7 |year=1995 |month=October |pmid=8619013 |doi= |url=]

Mechanism of action

Vesamicol can be broadly categorized as a cholinergic physiological antagonist, because it reduces the apparent activity of cholinergic neurons, but does not act at the post-synaptic ACh receptor. Vesamicol causes a non-competitive and reversible block of the intracellular transporter responsible for carrying newly synthesised ACh into storage vesicles in the pre-synaptic nerve terminal. This transport process is driven by a proton gradient between cell organelles and the cytoplasm.

References