NOTCH1

Notch homolog 1, translocation-associated (Drosophila), also known as NOTCH1, is a human gene encoding a single-pass transmembrane receptor.

PBB_Summary
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summary_text = This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [cite web | title = Entrez Gene: NOTCH1 Notch homolog 1, translocation-associated (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4851| accessdate = ] A deficiency can be associated with bicuspid aortic valve. cite journal |author=Stephen H. McKellar MD|title=Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms |journal=J Thorac Cardiovasc Surg.|volume=134 |issue=2 |pages=290-296 |year=2007 |month=August |pmid=17662764 |doi=10.1016/j.jtcvs.2007.02.041|url=]

There is evidence that activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia. cite journal |author=Tanigaki K, Nogaki F, Takahashi J, Tashiro K, Kurooka H, Honjo T |title=Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate |journal=Neuron |volume=29 |issue=1 |pages=45–55 |year=2001 |month=January |pmid=11182080 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/S0896-6273(01)00179-9] Interestingliy, Notch 1, then activated before birth, induces radial glia differentiation, cite journal |author=Gaiano N, Nye JS, Fishell G |title=Radial glial identity is promoted by Notch1 signaling in the murine forebrain |journal=Neuron |volume=26 |issue=2 |pages=395–404 |year=2000 |month=May |pmid=10839358 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/S0896-6273(00)81172-1] but postnatally induces the differentiation into astrocytes. cite journal |author=Chambers CB, Peng Y, Nguyen H, Gaiano N, Fishell G, Nye JS |title=Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors |journal=Development |volume=128 |issue=5 |pages=689–702 |year=2001 |month=March |pmid=11171394 |doi= |url=http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=11171394] One study shows that Notch-1 cascade is activated by Reelin in an undentified way. cite journal |author=Keilani S, Sugaya K |title=Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1 |journal=BMC Dev. Biol. |volume=8 |issue=1 |pages=69 |year=2008 |month=July |pmid=18593473 |doi=10.1186/1471-213X-8-69 |url=]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Artavanis-Tsakonas S, Rand MD, Lake RJ |title=Notch signaling: cell fate control and signal integration in development. |journal=Science |volume=284 |issue= 5415 |pages= 770–6 |year= 1999 |pmid= 10221902 |doi=
*cite journal | author=Mumm JS, Kopan R |title=Notch signaling: from the outside in. |journal=Dev. Biol. |volume=228 |issue= 2 |pages= 151–65 |year= 2001 |pmid= 11112321 |doi= 10.1006/dbio.2000.9960
*cite journal | author=Allenspach EJ, Maillard I, Aster JC, Pear WS |title=Notch signaling in cancer. |journal=Cancer Biol. Ther. |volume=1 |issue= 5 |pages= 466–76 |year= 2003 |pmid= 12496471 |doi=
*cite journal | author=Aster JC |title=Deregulated NOTCH signaling in acute T-cell lymphoblastic leukemia/lymphoma: new insights, questions, and opportunities. |journal=Int. J. Hematol. |volume=82 |issue= 4 |pages= 295–301 |year= 2006 |pmid= 16298817 |doi= 10.1532/IJH97.05096

External links

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