Pethidine Intermediate A

Pethidine Intermediate A

drugbox
IUPAC_name = 1-methyl-4-phenylpiperidine-4-carbonitrile



width = 160
CAS_number = 3627-62-1
synonyms = Pethidine Intermediate A
ATC_prefix =
ATC_suffix =
PubChem = 62513
DrugBank =
C = 13 | H = 16 | N = 2
molecular_weight = 200.28 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
excretion =
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US = Schedule I
legal_status =
routes_of_administration = N/A

Pethidine Intermediate A is a 4-phenylpiperidine derivative that is a precursor to the opioid analgesic drug pethidine (meperidine). It is not known to have any analgesic activity in its own right, however other derivatives of pethidine with a 4-cyano group in place of the carboxylate ethyl ester have been found to be active, [Lomenzo SA, Rhoden JB, Izenwasser S, Wade D, Kopajtic T, Katz JL, Trudell ML. Synthesis and Biological Evaluation of Meperidine Analogues at Monoamine Transporters. "Journal of Medicinal Chemistry". 2005; 48:1336-1343.] so Pethidine Intermediate A might also show opioid effects.

References


Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • Pethidine — Systematic (IUPAC) name …   Wikipedia

  • Opioid — Endogenous opioid peptides Skeletal molecular images Adrenorphin Amidorphin Casomorphin …   Wikipedia

  • Oxymorphone — Systematic (IUPAC) name 4,5α epoxy 3,14 dihydroxy 17 methylmorphinan 6 one Clinical data Trade names …   Wikipedia

  • Morphine — This article is about the drug. For other meanings, see Morphine (disambiguation). Morphia redirects here. For other uses, see Morphia (disambiguation). Not to be confused with Morphinae, Morphea, or Morpholine. Morphine …   Wikipedia

  • Phenoperidine — Systematic (IUPAC) name ethyl 1 (3 hydroxy 3 phenylpropyl) 4 phenylpiperidine 4 carboxylate Clinical data Pregnancy cat …   Wikipedia

  • Phencyclidine — Systematic (IUPAC) name …   Wikipedia

  • PEPAP — Systematic (IUPAC) name 4 phenyl 1 (2 phenylethyl)piperidin 4 yl acetate Clinical data Pregnancy cat.  ? …   Wikipedia

  • Racemorphan — Systematic (IUPAC) name (±) 17 methylmorphinan 3 ol Clinical data Pregnancy cat.  ? …   Wikipedia

  • Codeine — For other uses, see Codeine (disambiguation). Codeine Systematic (IUPAC) name (5α,6α) 7,8 didehydro 4,5 epoxy 3 methoxy 17 methylmorphinan 6 ol Cli …   Wikipedia

  • Tapentadol — Systematic (IUPAC) name 3 [(1R,2R) 3 (dimethylamino) 1 ethyl 2 …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”