TNFRSF1A

Tumor necrosis factor receptor superfamily, member 1A, also known as TNFRSF1A or CD120A, is a human gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription factor NF-kB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called periodic fever syndrome. Impaired receptor clearance is thought to be a mechanism of the disease. [cite web | title = Entrez Gene: TNFRSF1A tumor necrosis factor receptor superfamily, member 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7132| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

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citations =
*cite journal | author=Rath PC, Aggarwal BB |title=TNF-induced signaling in apoptosis. |journal=J. Clin. Immunol. |volume=19 |issue= 6 |pages= 350–64 |year= 2000 |pmid= 10634209 |doi=
*cite journal | author=Chen G, Goeddel DV |title=TNF-R1 signaling: a beautiful pathway. |journal=Science |volume=296 |issue= 5573 |pages= 1634–5 |year= 2002 |pmid= 12040173 |doi= 10.1126/science.1071924
*cite journal | author=Kollias G, Kontoyiannis D |title=Role of TNF/TNFR in autoimmunity: specific TNF receptor blockade may be advantageous to anti-TNF treatments. |journal=Cytokine Growth Factor Rev. |volume=13 |issue= 4-5 |pages= 315–21 |year= 2003 |pmid= 12220546 |doi=
*cite journal | author=Dodé C, Cuisset L, Delpech M, Grateau G |title=TNFRSF1A-associated periodic syndrome (TRAPS), Muckle-Wells syndrome (MWS) and renal amyloidosis. |journal=J. Nephrol. |volume=16 |issue= 3 |pages= 435–7 |year= 2003 |pmid= 12832748 |doi=
*cite journal | author=Stojanov S, McDermott MF |title=The tumour necrosis factor receptor-associated periodic syndrome: current concepts. |journal=Expert reviews in molecular medicine |volume=7 |issue= 22 |pages= 1–18 |year= 2007 |pmid= 16216134 |doi= 10.1017/S1462399405009749
*cite journal | author=Rezaei N |title=TNF-receptor-associated periodic syndrome (TRAPS): an autosomal dominant multisystem disorder. |journal=Clin. Rheumatol. |volume=25 |issue= 6 |pages= 773–7 |year= 2007 |pmid= 16447098 |doi= 10.1007/s10067-005-0198-6

External links

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