- Delta24(241)-sterol reductase
-
delta24(24-1) sterol reductase Identifiers EC number 1.3.1.71 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a Delta24(241)-sterol reductase (EC 1.3.1.71) is an enzyme that catalyzes the chemical reaction
- ergosterol + NADP+
ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
Thus, the two substrates of this enzyme are ergosterol and NADP+, whereas its 3 products are ergosta-5,7,22,24(241)-tetraen-3beta-ol, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ergosterol:NADP+ Delta24(241)-oxidoreductase. Other names in common use include sterol Delta24(28)-methylene reductase, and sterol Delta24(28)-reductase. This enzyme participates in biosynthesis of steroids.
References
- Neal WD, Parks LW (1977). "Sterol 24(28) methylene reductase in Saccharomyces cerevisiae". J. Bacteriol. 129 (3): 1375–8. PMC 235112. PMID 14922. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=235112.
- Zweytick D, Hrastnik C, Kohlwein SD, Daum G (2000). "Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast saccharomyces cerevisiae". FEBS. Lett. 470 (1): 83–7. doi:10.1016/S0014-5793(00)01290-4. PMID 10722850.
This EC 1.3 enzyme-related article is a stub. You can help Wikipedia by expanding it. - ergosterol + NADP+
