Kynurenine 3-monooxygenase
- Kynurenine 3-monooxygenase
In enzymology, a kynurenine 3-monooxygenase (EC number|1.14.13.9) is an enzyme that catalyzes the chemical reaction
:L-kynurenine + NADPH + H+ + O2 3-hydroxy-L-kynurenine + NADP+ + H2O
The 4 substrates of this enzyme are L-kynurenine, NADPH, H+, and O2, whereas its 3 products are 3-hydroxy-L-kynurenine, NADP+, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating). Other names in common use include kynurenine 3-hydroxylase, kynurenine hydroxylase, and L-kynurenine-3-hydroxylase. This enzyme participates in tryptophan metabolism. It employs one cofactor, FAD.
References
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External links
::"The CAS registry number for this enzyme class is CAS registry|9029-61-2."
Gene Ontology (GO) codes
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kynurenine 3-monooxygenase — kyn·ure·nine 3 mono·oxy·gen·ase (kīn uґrə nēn″ mon″o okґsĭ jən ās) [EC 1.14.13.9] an enzyme of the oxidoreductase class that catalyzes the hydroxylation of kynurenine as a step in the metabolism of… … Medical dictionary
kynurenine 3-hydroxylase — kyn·ure·nine 3 hy·drox·y·lase (kīn uґrə nēn″ hi drokґsĭ lās) kynurenine 3 monooxygenase … Medical dictionary
kynurenine — A product of the metabolism of l tryptophan, excreted in the urine in small amounts; elevated in cases of vitamin B6 deficiency. k. formamidase SYN: formamidase. k. 3 hydroxylase SYN: k. 3 monooxygenase. k. 3 monooxygenase an enzyme catalyzing… … Medical dictionary
Kynurenin-3-Monooxygenase — Masse/Länge Primärstruktur 486 Aminosäuren … Deutsch Wikipedia
KMO (gene) — Kynurenine 3 monooxygenase (kynurenine 3 hydroxylase), also known as KMO, is a human gene.cite web | title = Entrez Gene: KMO kynurenine 3 monooxygenase (kynurenine 3 hydroxylase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… … Wikipedia
List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH … Wikipedia
3-hydroxykynurénine — Structure de la 3 hydroxy L kynurénine Général Nom IUPAC acide 2 amino 4 (2 amino 3 hydro … Wikipédia en Français
List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… … Wikipedia
5HTP — Strukturformel … Deutsch Wikipedia
5hydroxytryptophan — Strukturformel … Deutsch Wikipedia
