BRAF (gene)

V-raf murine sarcoma viral oncogene homolog B1, also known as BRAF, is a human gene.

The BRAF gene makes a protein called B-RAF, which is involved in sending signals in cells and in cell growth. This gene may be mutated [ [http://www.pnas.org/cgi/external_ref?access_num=12068308&link_type=MED] Davies H, et al. (2002) Mutations of the BRAF gene in human cancer. Nature 417:949–954.] (changed) in many types of cancer, which causes a change in the B-RAF protein. This can increase the growth and spread of cancer cells.

Some pharmaceutical firms are doing basic research to develop specific inhibitors of B-raf protein for anticancer use. [ [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17145850] King AJ et al. (2006) Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res. 66(23):11100-5.] [ [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18287029] Tsai, J et al. (2008) Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc.Natl.Acad.Sci.USA 105: 3041-3046]

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References

Further reading

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*cite journal | author=Sithanandam G, Kolch W, Duh FM, Rapp UR |title=Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies |journal=Oncogene |volume=5 |issue= 12 |pages= 1775–80 |year= 1991 |pmid= 2284096 |doi=
*cite journal | author=Garnett MJ, Marais R |title=Guilty as charged: B-RAF is a human oncogene |journal=Cancer Cell |volume=6 |issue= 4 |pages= 313–9 |year= 2004 |pmid= 15488754 |doi= 10.1016/j.ccr.2004.09.022
*cite journal | author=Quiros RM, Ding HG, Gattuso P, "et al." |title=Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations |journal=Cancer |volume=103 |issue= 11 |pages= 2261–8 |year= 2005 |pmid= 15880523 |doi= 10.1002/cncr.21073
*cite journal | author=Karbowniczek M, Henske EP |title=The role of tuberin in cellular differentiation: are B-Raf and MAPK involved? |journal=Ann. N. Y. Acad. Sci. |volume=1059 |issue= |pages= 168–73 |year= 2006 |pmid= 16382052 |doi= 10.1196/annals.1339.045
*cite journal | author=Ciampi R, Nikiforov YE |title=RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis |journal=Endocrinology |volume=148 |issue= 3 |pages= 936–41 |year= 2007 |pmid= 16946010 |doi= 10.1210/en.2006-0921
*cite journal | author=Espinosa AV, Porchia L, Ringel MD |title=Targeting BRAF in thyroid cancer |journal=Br. J. Cancer |volume=96 |issue= 1 |pages= 16–20 |year= 2007 |pmid= 17179987 |doi= 10.1038/sj.bjc.6603520

External links

* cite web
url = http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=561325
title = BRAF gene
publisher = NCI Dictionary of Cancer Terms
accessdate=2007-11-25

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