HCK

Hemopoietic cell kinase, also known as HCK, is a human gene.

PBB_Summary
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summary_text = The protein encoded by this gene is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization. [cite web | title = Entrez Gene: HCK hemopoietic cell kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3055| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Geyer M, Fackler OT, Peterlin BM |title=Structure--function relationships in HIV-1 Nef. |journal=EMBO Rep. |volume=2 |issue= 7 |pages= 580–5 |year= 2001 |pmid= 11463741 |doi= 10.1093/embo-reports/kve141
*cite journal | author=Lake JA, Carr J, Feng F, "et al." |title=The role of Vif during HIV-1 infection: interaction with novel host cellular factors. |journal=J. Clin. Virol. |volume=26 |issue= 2 |pages= 143–52 |year= 2003 |pmid= 12600646 |doi=
*cite journal | author=Greenway AL, Holloway G, McPhee DA, "et al." |title=HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication. |journal=J. Biosci. |volume=28 |issue= 3 |pages= 323–35 |year= 2004 |pmid= 12734410 |doi=
*cite journal | author=Tolstrup M, Ostergaard L, Laursen AL, "et al." |title=HIV/SIV escape from immune surveillance: focus on Nef. |journal=Curr. HIV Res. |volume=2 |issue= 2 |pages= 141–51 |year= 2004 |pmid= 15078178 |doi=
*cite journal | author=Joseph AM, Kumar M, Mitra D |title=Nef: "necessary and enforcing factor" in HIV infection. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 87–94 |year= 2005 |pmid= 15638726 |doi=
*cite journal | author=Stove V, Verhasselt B |title=Modelling thymic HIV-1 Nef effects. |journal=Curr. HIV Res. |volume=4 |issue= 1 |pages= 57–64 |year= 2006 |pmid= 16454711 |doi=
*cite journal | author=Lichtenberg U, Quintrell N, Bishop JM |title=Human protein-tyrosine kinase gene HCK: expression and structural analysis of the promoter region. |journal=Oncogene |volume=7 |issue= 5 |pages= 849–58 |year= 1992 |pmid= 1373873 |doi=
*cite journal | author=Hradetzky D, Strebhardt K, Rübsamen-Waigmann H |title=The genomic locus of the human hemopoietic-specific cell protein tyrosine kinase (PTK)-encoding gene (HCK) confirms conservation of exon-intron structure among human PTKs of the src family. |journal=Gene |volume=113 |issue= 2 |pages= 275–80 |year= 1992 |pmid= 1572549 |doi=
*cite journal | author=Kim JW, Sim SS, Kim UH, "et al." |title=Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro. |journal=J. Biol. Chem. |volume=265 |issue= 7 |pages= 3940–3 |year= 1990 |pmid= 1689310 |doi=
*cite journal | author=Holtrich U, Bräuninger A, Strebhardt K, Rübsamen-Waigmann H |title=Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 23 |pages= 10411–5 |year= 1992 |pmid= 1720539 |doi=
*cite journal | author=Lock P, Ralph S, Stanley E, "et al." |title=Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization. |journal=Mol. Cell. Biol. |volume=11 |issue= 9 |pages= 4363–70 |year= 1991 |pmid= 1875927 |doi=
*cite journal | author=Ziegler SF, Marth JD, Lewis DB, Perlmutter RM |title=Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin. |journal=Mol. Cell. Biol. |volume=7 |issue= 6 |pages= 2276–85 |year= 1987 |pmid= 3453117 |doi=
*cite journal | author=Quintrell N, Lebo R, Varmus H, "et al." |title=Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells. |journal=Mol. Cell. Biol. |volume=7 |issue= 6 |pages= 2267–75 |year= 1987 |pmid= 3496523 |doi=
*cite journal | author=Lee CH, Leung B, Lemmon MA, "et al." |title=A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. |journal=EMBO J. |volume=14 |issue= 20 |pages= 5006–15 |year= 1995 |pmid= 7588629 |doi=
*cite journal | author=Liao F, Shin HS, Rhee SG |title=In vitro tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2 by src-family protein tyrosine kinases. |journal=Biochem. Biophys. Res. Commun. |volume=191 |issue= 3 |pages= 1028–33 |year= 1993 |pmid= 7682059 |doi= 10.1006/bbrc.1993.1320
*cite journal | author=Briggs SD, Bryant SS, Jove R, "et al." |title=The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck. |journal=J. Biol. Chem. |volume=270 |issue= 24 |pages= 14718–24 |year= 1995 |pmid= 7782336 |doi=
*cite journal | author=Robbins SM, Quintrell NA, Bishop JM |title=Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae. |journal=Mol. Cell. Biol. |volume=15 |issue= 7 |pages= 3507–15 |year= 1995 |pmid= 7791757 |doi=
*cite journal | author=Saksela K, Cheng G, Baltimore D |title=Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4. |journal=EMBO J. |volume=14 |issue= 3 |pages= 484–91 |year= 1995 |pmid= 7859737 |doi=
*cite journal | author=Cheng G, Ye ZS, Baltimore D |title=Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 17 |pages= 8152–5 |year= 1994 |pmid= 8058772 |doi=
*cite journal | author=Wang AV, Scholl PR, Geha RS |title=Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn. |journal=J. Exp. Med. |volume=180 |issue= 3 |pages= 1165–70 |year= 1994 |pmid= 8064233 |doi=

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