Enadoline

Drugbox
IUPAC_name = 2-(benzofuran-4-yl)-N-methyl-N-((5R,7S,8S)-7-(pyrrolidin-1-yl)-1-oxaspiro [4.5] decan-8-yl)ethanamide


width = 200
CAS_number = 124378-77-4
smiles = O=C(Cc1cccc2occc12)N(C)C1CCC2(CCCO2)CC1N1CCCC1
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PubChem = 60768
DrugBank =
C=24|H=32|N=2|O=3
molecular_weight = 396.52 g/mol
bioavailability =
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Enadoline is a drug which acts as a highly selective κ-opioid agonist.

In human studies, it produced visual distortions and feelings of dissociation, reminiscent of the effects of Salvinorin-A.cite journal
author=Walsh SL, Strain EC, Abreu ME, Bigelow GE
title=Enadoline, a selective kappa opioid agonist: comparison with butorphanol and hydromorphone in humans
journal=Psychopharmacology (Berl.)
volume=157
issue=2
pages=151–62
year=2001
pmid=11594439
doi=]

It was looked at as a potential analgesic, but abandoned because of the dose-limiting effects of dysphoria, which could be expected from a κ-opioid agonist. There was mention of its potential in treating comatose head injury or stroke victims, where that type of side effect would be immaterial.cite journal
author=Barber A, Gottschlich R
title=Novel developments with selective, non-peptidic kappa-opioid receptor agonists
journal=Expert Opin Investig Drugs
volume=6
issue=10
pages=1351–68
year=1997
pmid=15989506
doi=10.1517/13543784.6.10.1351]

ee also

* Salvinorin A

References